Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 137, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104661
Keywords
Meta-analysis; Neonatal pain; Morphine; Preterm infants; Neonatal sedation; Apoptosis; Motor outcome; Behavioral outcome
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This systematic review and meta-analysis found that neonatal exposure to pain is associated with increased neuronal cell death, and higher number of pain events is significantly correlated with increased neuronal cell death, anxiety, and depressant-like behavior in rodents. However, opiates and pain have no impact on motor function.
This systematic review and meta-analysis aimed to investigate the association of neonatal exposure to pain, stress, opiate administration alone, as well as opiate administration prior to a painful procedure on neuronal cell death, motor, and behavioral outcomes in rodents. In total, 36 studies investigating the effect of pain (n = 18), stress (n = 15), opiate administration (n = 13), as well as opiate administration prior to a painful event (n = 7) in rodents were included in our meta-analysis. The results showed a large effect of pain (g = 1.37, 95% CI 1.00-1.74, p < .001) on neuronal cell death. Moreover, higher number of neonatal pain events were significantly associated with increased neuronal cell death, increased anxiety (b =-1.18, SE = 0.43, p = .006), and depressant-like behavior (b = 1.74, SE = 0.51, p = .027) in rodents. Both opiates and pain had no impact on motor function (g = 0.26, 95% CI 0.18-0.70, p = .248).
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