Journal
NEUROPHARMACOLOGY
Volume 208, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2022.108997
Keywords
Norepinephrine; Opioids; Psychostimulants; Alcohol; Locus coeruleus; Nucleus of the tractus solitarius
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This review discusses recent advances in understanding the role of the noradrenergic system in substance use disorders, including potential therapeutic targets and new treatment approaches.
The central noradrenergic system innervates almost all regions of the brain and, as such, is well positioned to modulate many neural circuits implicated in behaviors and physiology underlying substance use disorders. Ample pharmacological evidence demonstrates that alpha 1, alpha 2, and beta adrenergic receptors may serve as therapeutic targets to reduce drug -seeking behavior and drug withdrawal symptoms. Further, norepinephrine is a key modulator of the stress response, and stress has been heavily implicated in reinstatement of drug taking. In this review, we discuss recent advances in our understanding of noradrenergic circuitry and noradrenergic receptor signaling in the context of opioid, alcohol, and psychostimulant use disorders.
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