Deja vu'' in an autism gene mouse model modifies social mores

Genetic and environmental factors during development are involved in autism, and in this issue of Neuron Kruttner et al. (2022) find environment may play a more acute role in modulating autism behavior in a Shank3 exon 21 deletion mutant mouse (Shank3(Delta C/Delta C)). The authors explore the underlying circuit mechanisms in detail.

Automated summary

This study suggests that environmental factors play a more significant role than genetics in modulating autism behavior, and the underlying neural circuit mechanisms are investigated in detail.