4.8 Article

Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease

Related references

Note: Only part of the references are listed.
Article Neurosciences

Molecular characterization of selectively vulnerable neurons in Alzheimer's disease

Kun Leng et al.

Summary: The study reveals the molecular signature of neuronal subpopulations vulnerable to tau aggregation and death in Alzheimer's disease, validating RORB as a marker. Using single-nucleus RNA sequencing, the research identified and characterized vulnerable neurons in the entorhinal cortex, as well as a subpopulation of astrocytes likely representing reactive astrocytes.

NATURE NEUROSCIENCE (2021)

Article Clinical Neurology

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease

Emma Gerrits et al.

Summary: This study conducted single-nuclei RNA sequencing on Alzheimer's disease (AD)-related human microglia, revealing two distinct expression profiles associated with pathology. These findings shed light on the role of microglia in AD and offer new targets for microglia-specific therapeutic strategies.

ACTA NEUROPATHOLOGICA (2021)

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes induce cell death via saturated lipids

Kevin A. Guttenplan et al.

Summary: Astrocytes respond to diseases and injuries in the central nervous system by releasing long-chain saturated fatty acids contained in lipoparticles, leading to the death of neurons and mature oligodendrocytes. The elimination of saturated lipids produced by astrocytes can mitigate astrocyte-induced toxicity, suggesting a mechanism by which astrocytes kill cells in the central nervous system.

NATURE (2021)

Article Neurosciences

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

Kristen R. Maynard et al.

Summary: This study defined spatial gene expression in the human dorsolateral prefrontal cortex, revealing layer-enriched expression of genes associated with schizophrenia and autism, highlighting the clinical relevance of spatially defined expression.

NATURE NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Integrated analysis of multimodal single-cell data

Yuhan Hao et al.

Summary: The study introduces a weighted-nearest neighbor analysis framework to learn the relative utility of each data type in each cell, enabling integrative analysis of multiple modalities. Applied to a CITE-seq dataset, the method constructs a multimodal reference atlas of the circulating immune system and successfully identifies and validates previously unreported lymphoid subpopulations.
Article Biotechnology & Applied Microbiology

Spatial transcriptomics at subspot resolution with BayesSpace

Edward Zhao et al.

Summary: BayesSpace increases the resolution of spatial transcriptomics by utilizing neighborhood information. It outperforms current methods for spatial and non-spatial clustering, improving the identification of distinct intra-tissue transcriptional profiles. BayesSpace can resolve tissue structures undetectable at the original resolution and identify transcriptional heterogeneity inaccessible to histological analysis.

NATURE BIOTECHNOLOGY (2021)

Article Neurosciences

Neuroinflammatory astrocyte subtypes in the mouse brain

Philip Hasel et al.

Summary: This study investigated the transcriptome changes of mouse cortical astrocytes after an acute inflammatory stimulus, revealing rapid and drastic changes over time. By sequencing thousands of astrocytes at single-cell resolution, it was shown that inflammation causes a widespread response with distinct subtypes undergoing inflammatory transitions with defined transcriptomic profiles. Spatial transcriptomics and in situ hybridization were used to attribute specific inflammation-induced reactive astrocyte sub-states to certain brain regions.

NATURE NEUROSCIENCE (2021)

Article Clinical Neurology

2021 Alzheimer's disease facts and figures

[Anonymous]

Summary: Alzheimer's disease has a significant impact on individuals and society as a whole, with a large number of patients in the United States and a potential for continued growth in the future. The value of unpaid caregivers has increased despite a decline in their numbers, and healthcare costs are on the rise. Racial and ethnic disparities in healthcare persist, highlighting the need for greater diversity in dementia care workforce and clinical trials.

ALZHEIMERS & DEMENTIA (2021)

Article Biochemical Research Methods

Orchestrating single-cell analysis with Bioconductor

Robert A. Amezquita et al.

NATURE METHODS (2020)

Article Multidisciplinary Sciences

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

Kevin A. Guttenplan et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease

Shun-Fat Lau et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Association of APOE e2 genotype with Alzheimer's and non-Alzheimer's neurodegenerative pathologies

Terry E. Goldberg et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation

Caroline E. Nunes-Xavier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Single-cell transcriptomic analysis of Alzheimer's disease

Hansruedi Mathys et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Comprehensive Integration of Single-Cell Data

Tim Stuart et al.

Article Multidisciplinary Sciences

Conserved cell types with divergent features in human versus mouse cortex

Rebecca D. Hodge et al.

NATURE (2019)

Article Clinical Neurology

A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain

Jorge L. Del-Aguila et al.

ALZHEIMERS RESEARCH & THERAPY (2019)

Article Clinical Neurology

Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

LeeAnn Ramsay et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2019)

Article Biochemical Research Methods

Fast, sensitive and accurate integration of single-cell data with Harmony

Ilya Korsunsky et al.

NATURE METHODS (2019)

Article Cell Biology

Astrocyte molecular signatures in Huntington's disease

Blanca Diaz-Castro et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Review Pharmacology & Pharmacy

Don't forget astrocytes when targeting Alzheimer's disease

Jessica S. Sadick et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

Article Biotechnology & Applied Microbiology

Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression

Christoph Hafemeister et al.

GENOME BIOLOGY (2019)

Article Chemistry, Medicinal

Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease

Yinuo Wu et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Normal aging induces A1-like astrocyte reactivity

Laura E. Clarke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

A general and flexible method for signal extraction from single-cell RNA-seq data

Davide Risso et al.

NATURE COMMUNICATIONS (2018)

Article Cell Biology

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

Matthew M. Boisvert et al.

CELL REPORTS (2018)

Review Neurosciences

SALM/Lrfn Family Synaptic Adhesion Molecules

Eunkyung Lie et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Neurosciences

The Emerging Role of Mechanics in Synapse Formation and Plasticity

Devrim Kilinc

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Pharmacology & Pharmacy

Investigational phosphodiesterase inhibitors in phase I and phase II clinical trials for Alzheimer's disease

Jos Prickaerts et al.

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2017)

Article Multidisciplinary Sciences

Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

Jeff A. Stogsdill et al.

NATURE (2017)

Article Multidisciplinary Sciences

Neurotoxic reactive astrocytes are induced by activated microglia

Shane A. Liddelow et al.

NATURE (2017)

Review Neurosciences

Involvement of Astrocytes in Alzheimer's Disease from a Neuroinflammatory and Oxidative Stress Perspective

Rodrigo E. Gonzalez-Reyes et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

QuPath: Open source software for digital pathology image analysis

Peter Bankhead et al.

SCIENTIFIC REPORTS (2017)

Article Cell & Tissue Engineering

Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease

Scott E. Counts et al.

CELL TRANSPLANTATION (2017)

Article Biochemistry & Molecular Biology

Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model

Loqman A. Mohamed et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

Article Biochemical Research Methods

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

Zuguang Gu et al.

BIOINFORMATICS (2016)

Review Biochemistry & Molecular Biology

The Cellular Phase of Alzheimer's Disease

Bart De Strooper et al.

Review Neurosciences

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

Christopher S. von Bartheld et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2016)

Review Clinical Neurology

Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease

Niklas Mattsson et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2016)

Article Neurosciences

A rapid and cost-effective method for genotyping apolipoprotein E gene polymorphism

Li Zhong et al.

MOLECULAR NEURODEGENERATION (2016)

Article Multidisciplinary Sciences

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Soyon Hong et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh et al.

SCIENCE (2016)

Article Geriatrics & Gerontology

Galantamine attenuates amyloid-β deposition and astrocyte activation in APP/PS1 transgenic mice

Zhaoxuan Wu et al.

EXPERIMENTAL GERONTOLOGY (2015)

Review Neurosciences

The promise of stem cells in the therapy of Alzheimer's disease

Chunmei Yue et al.

TRANSLATIONAL NEURODEGENERATION (2015)

Article Biochemistry & Molecular Biology

Targeted quantitative analysis of synaptic proteins in Alzheimer's disease brain

Rachel Yoon Kyung Chang et al.

NEUROCHEMISTRY INTERNATIONAL (2014)

Article Medicine, Research & Experimental

Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

Yasir A. Syed et al.

EMBO MOLECULAR MEDICINE (2013)

Article Clinical Neurology

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

Peter T. Nelson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2013)

Article Medicine, Research & Experimental

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

Azeb Tadesse Argaw et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Neurosciences

Genomic Analysis of Reactive Astrogliosis

Jennifer L. Zamanian et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Ursula Fuenfschilling et al.

NATURE (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Clinical Neurology

Cerebral amyloid angiopathy in the elderly

Anand Viswanathan et al.

ANNALS OF NEUROLOGY (2011)

Review Clinical Neurology

Cholesterol: A Novel Regulatory Role in Myelin Formation

Gesine Saher et al.

NEUROSCIENTIST (2011)

Article Biochemical Research Methods

High Degree of Heterogeneity in Alzheimer's Disease Progression Patterns

Natalia L. Komarova et al.

PLOS COMPUTATIONAL BIOLOGY (2011)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

DISC1 regulates N-cadherin and β1-integrin expression in neurons

T Hattori et al.

MOLECULAR PSYCHIATRY (2010)

Article Multidisciplinary Sciences

Polyamine pathway contributes to the pathogenesis of Parkinson disease

Nicole M. Lewandowski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Endocrinology & Metabolism

Biochemical and physiological function of stearoyl-CoA desaturase

Chad M. Paton et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Biochemical Research Methods

Mapping identifiers for the integration of genomic datasets with the R/Bioconductor package biomaRt

Steffen Durinck et al.

NATURE PROTOCOLS (2009)

Article Pharmacology & Pharmacy

Phosphodiesterase inhibitors

V Boswell-Smith et al.

BRITISH JOURNAL OF PHARMACOLOGY (2006)

Article Geriatrics & Gerontology

Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

HM Schipper et al.

NEUROBIOLOGY OF AGING (2006)

Article Neurosciences

High cholesterol level is essential for myelin membrane growth

G Saher et al.

NATURE NEUROSCIENCE (2005)

Article Biochemistry & Molecular Biology

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

HY Jiang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Review Neurosciences

New roles for astrocytes: Redefining the functional architecture of the brain

M Nedergaard et al.

TRENDS IN NEUROSCIENCES (2003)

Article Biochemistry & Molecular Biology

Cholesterol, a modulator of membrane-associated Aβ-fibrillogenesis and neurotoxicity

CM Yip et al.

JOURNAL OF MOLECULAR BIOLOGY (2001)

Review Neurosciences

Cerebral microvascular pathology in aging and Alzheimer's disease

E Farkas et al.

PROGRESS IN NEUROBIOLOGY (2001)

Article Neurosciences

N-cadherin is involved in axon-oligodendrocyte contact and myelination

O Schnädelbach et al.

MOLECULAR AND CELLULAR NEUROSCIENCE (2001)

Article Medicine, Research & Experimental

VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain

ZG Zhang et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)