Back-to-BACs in Huntington's disease modeling

In this issue of Neuron, Gu et al. (2022) describe a new BAC mouse model that faithfully recapitulates various aspects of Huntington's disease pathobiology and reveals important insights into the relative toxicities of mHTT-derived products.

Automated summary

In this study, the authors present a novel BAC mouse model that accurately recapitulates various aspects of Huntington's disease and provides important insights into the relative toxicities of mHTT-derived products.