4.7 Article

Time Course for Benefit and Risk of Ticagrelor and Aspirin in Acute Ischemic Stroke or Transient Ischemic Attack

Related references

Note: Only part of the references are listed.
Review Clinical Neurology

A 5-Decade Analysis of Incidence Trends of Ischemic Stroke After Transient Ischemic Attack A Systematic Review and Meta-analysis

Shima Shahjouei et al.

Summary: This study found that the incidence of ischemic stroke following a transient ischemic attack (TIA) was 2.4% within 2 days, 3.8% within 7 days, 4.1% within 30 days, and 4.7% within 90 days. The rate of post-TIA stroke may have slightly decreased over the past two decades.

JAMA NEUROLOGY (2021)

Review Cardiac & Cardiovascular Systems

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials

Gabriela Trifan et al.

Summary: For patients with minor noncardioembolic stroke, dual antiplatelet treatment with aspirin plus clopidogrel reduces the risk of recurrent stroke and composite events compared to monotherapy, but increases the risk of major bleeding, especially when the treatment duration exceeds 30 days or includes the combination of aspirin plus ticagrelor.

CIRCULATION (2021)

Article Clinical Neurology

Ischemic Benefit and Hemorrhage Risk of Ticagrelor-Aspirin Versus Aspirin in Patients With Acute Ischemic Stroke or Transient Ischemic Attack

S. Claiborne Johnston et al.

Summary: The THALES trial showed that adding ticagrelor to aspirin in acute mild-moderate ischemic stroke or high-risk transient ischemic attack patients reduced the risk of stroke or death compared to placebo. Although there was an increased risk of severe hemorrhage, the overall net clinical impact favored ticagrelor-aspirin treatment.

STROKE (2021)

Review Clinical Neurology

2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association

Dawn O. Kleindorfer et al.

Summary: Additional digital content is available in the text.

STROKE (2021)

Article Clinical Neurology

European Stroke Organisation expedited recommendation for the use of short-term dual antiplatelet therapy early after minor stroke and high-risk TIA

Jesse Dawson et al.

Summary: It is strongly recommended to use aspirin and clopidogrel dual antiplatelet therapy for 21 days in patients with non-cardioembolic minor ischemic stroke or high-risk TIA in the past 24 hours, based on high quality evidence. It is weakly recommended to use aspirin and ticagrelor dual antiplatelet therapy for 30 days in patients with non-cardioembolic mild to moderate ischemic stroke or high-risk TIA in the past 24 hours, based on moderate quality evidence.

EUROPEAN STROKE JOURNAL (2021)

Editorial Material Medicine, General & Internal

Antiplatelet Therapy after Ischemic Stroke or TIA

James C. Grotta

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA

S. Claiborne Johnston et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

Pierre Amarenco et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack

Yongjun Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Hematology

Platelet function testing and risk of bleeding complications

Jose Luis Ferreiro et al.

THROMBOSIS AND HAEMOSTASIS (2010)

Editorial Material Medicine, General & Internal

Weighing Benefits and Risks -- The FDA's Review of Prasugrel.

Ellis F. Unger

NEW ENGLAND JOURNAL OF MEDICINE (2009)