Journal
NEUROLOGICAL SCIENCES
Volume 43, Issue 8, Pages 4863-4874Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-022-06027-6
Keywords
Ischaemic stroke; TIA; Recurrent stroke; Cerebral small vascular disease; Infarction number
Categories
Funding
- National Natural Science Foundation of China [81825007]
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910025030]
- Youth Beijing Scholar Program [010]
- Beijing Talent Project -Class A: Innovation and Development [2018A12]
- National Key R&D Program of China [2017YFC1307900,2017YFC1307905]
Ask authors/readers for more resources
This study investigated the association between different statuses of cerebral small vessel disease (CSVD) and infarction number with recurrence after acute minor stroke and transient ischaemic attack (TIA). The results showed that patients with coexistent CSVD and multiple acute infarctions (MAIs) had a significantly higher risk of recurrent stroke within 1 year. These findings are important for predicting the risk of recurrence in patients.
Background and purpose To investigate the association of different status of cerebral small vessel disease (CSVD) and infarction number with recurrence after acute minor stroke and transient ischaemic attack (TIA). Methods This study was a post hoc analysis of the Clopidogrel in High-risk Patients with Acute Nondisabling Cerebrovascular Events (CHANCE) trial, and includes 886 patients with acute minor stroke and TIA. The status of CSVD and infarction number was recorded for each individual. Infarction number were classified as multiple acute infarctions (MAIs >= 2), single acute infarction (SAI =1), and non-acute infarction (NAI =0). The CSVD burden were grouped into non-CSVD (0 score) and CSVD (1-4 score). The primary outcome was a recurrent stroke at the 1-year follow-up. The secondary outcomes were recurrent ischaemic stroke, composite vascular event (CVE), and TIA. We analyzed the relationships between different status of CSVD burden and infarction pattern with the risk of outcomes using multivariable Cox regression models. Results Among all 886 patients included in present analysis, recurrent stroke was occurred in 93 (10.5%) patients during 1-year follow-up. After adjusted for all potential covariates, compared with patients with non-CSVD and NAI, patients with CSVD and MAIs were associated with approximately 9.5-fold increased risk of recurrent stroke at 1 year (HR 9.560, 95% CI 1.273-71.787, p=0.028). Similar results observed in ischaemic stroke and CVE. Conclusion The status of CSVD and infarction number predicted recurrent stroke in patients with acute minor stroke and TIA, especially for those with coexistent CSVD and MAIs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available