Journal
NEUROIMAGE
Volume 252, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.119030
Keywords
Common marmoset; Functional connectivity; Non-human primate; Open-access data resource; Resting-state functional magnetic resonance; imaging
Funding
- Canadian Institutes of Health Research [FRN 148365, FRN 353372]
- Canada First Research Excellence Fund
- Pennsylvania Department of Health Commonwealth Universal Research Enhancement [SAP 4100083102]
- NIH, National Institute of Neurological Disorders and Stroke
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The Marmoset Functional Brain Connectivity Resource is an important tool for studying the functional and structural organization of the marmoset brain. It provides a large dataset of resting-state fMRI data, allowing users to view, manipulate, and download the data, as well as test hypotheses about functional connectivity.
The common marmoset (Callithrix jacchus) is quickly gaining traction as a premier neuroscientific model. However, considerable progress is still needed in understanding the functional and structural organization of the marmoset brain to rival that documented in longstanding preclinical model species, like mice, rats, and Old World primates. To accelerate such progress, we present the Marmoset Functional Brain Connectivity Resource ( marmosetbrainconnectome.org ), currently consisting of over 70 h of resting-state fMRI (RS-fMRI) data acquired at 500 mu m isotropic resolution from 31 fully awake marmosets in a common stereotactic space. Three-dimensional functional connectivity (FC) maps for every cortical and subcortical gray matter voxel are stored online. Users can instantaneously view, manipulate, and download any whole-brain functional connectivity (FC) topology (at the subject-or group-level) along with the raw datasets and preprocessing code. Importantly, researchers can use this resource to test hypotheses about FC directly - with no additional analyses required - yielding whole-brain correlations for any gray matter voxel on demand. We demonstrate the resource's utility for presurgical planning and comparison with tracer-based neuronal connectivity as proof of concept. Complementing existing structural connectivity resources for the marmoset brain, the Marmoset Functional Brain Connectivity Resource affords users the distinct advantage of exploring the connectivity of any voxel in the marmoset brain, not limited to injection sites nor constrained by regional atlases. With the entire raw database (RS-fMRI and structural images) and preprocessing code openly available for download and use, we expect this resource to be broadly valuable to test novel hypotheses about the functional organization of the marmoset brain.
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