Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome

Abnormalities of mast cell structure or function may play prominent roles in irritable bowel syndrome (IBS) symptom genesis. Mast cells show close apposition to sensory nerves and release bioactive substances in response to varied stimuli including infection, stress, and other neuroendocrine factors. Most studies focus on patients who develop IBS after enteric infection or who report diarrhea-predominant symptoms. Three topics underlying IBS pathogenesis have been emphasized in recent investigations. Visceral hypersensitivity to luminal stimulation is found in most IBS patients and may contribute to abdominal pain. Mast cell dysfunction also may disrupt epithelial barrier function which alters mucosal permeability potentially leading to altered bowel function and pain. Mast cell products including histamine, proteases, prostaglandins, and cytokines may participate in hypersensitivity and permeability defects, especially with diarrhea-predominant IBS. Recent experimental evidence indicates that the pronociceptive effects of histamine and proteases are mediated by the generation of prostaglandins in the mast cell. Enteric microbiome interactions including increased mucosal bacterial translocation may activate mast cells to elicit inflammatory responses underlying some of these pathogenic effects. Therapies to alter mast cell activity (mast cell stabilizers) or function (histamine antagonists) have shown modest benefits in IBS. Future investigations will seek to define patient subsets with greater potential to respond to therapies that address visceral hypersensitivity, epithelial permeability defects, and microbiome alterations secondary to mast cell dysfunction in IBS.

Automated summary

Abnormalities in mast cell structure or function may play a significant role in the development of irritable bowel syndrome (IBS) symptoms. Mast cells, which release bioactive substances in response to various stimuli, are closely associated with sensory nerves. Visceral hypersensitivity, disrupted epithelial barrier function, and mast cell products including histamine, proteases, prostaglandins, and cytokines are all linked to the pathogenesis of IBS. Furthermore, interactions between the enteric microbiome and mast cells may induce inflammatory responses that contribute to these effects. Therapies targeting mast cell activity or function have shown modest benefits in alleviating IBS symptoms.