Journal
NEUROCHEMICAL RESEARCH
Volume 47, Issue 12, Pages 3627-3634Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-022-03586-0
Keywords
alpha-synuclein aggregation; Brain; Peripheral tissues; Parkinson; S disease
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Funding
- NHC Key Laboratory of Drug Addiction Medicine, The First Affiliated Hospital of Kunming Medical University, Kunming, China [2020DAMOP-008]
- National Natural Science Foundation of China [81773925, 81730096]
- Beijing Natural Science Foundation [7212156]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2021-1-I2M-026]
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This review summarizes the distribution of alpha-synuclein in the central nervous system and peripheral tissues of Parkinson's disease patients, and discusses the aggregation mechanism, providing a basis for early diagnosis and intervention.
Parkinson's disease (PD) is a chronic neurodegenerative disease mainly characterized by movement disorders and other non-motor symptoms, including the loss of dopaminergic neurons in the substantia nigra parts. Abnormal alpha-synuclein aggregation in the brain is closely associated with the loss of dopaminergic neurons. alpha-synuclein can propagate in the central nervous system (CNS) and periphery under pathological conditions. Many researches have focused on its aggregation and distribution in the CNS and explored its relationship with PD. But in recent years, the distribution of alpha-synuclein in peripheral tissues have been paid much attention. This review summarized the distribution of alpha-synuclein in the choroid plexus, blood, saliva, gastrointestine and other tissues, and discussed the potential mechanism of alpha-synuclein aggregation, providing a basis for the early diagnosis and intervention of PD.
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