Journal
NEUROBIOLOGY OF DISEASE
Volume 166, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2022.105650
Keywords
L-DOPA-induced dyskinesia; Dystonia; Synaptic dysfunction; Synaptic plasticity; Neurotransmitters; Receptors; Striatum; Basal ganglia; Parkinson's disease
Categories
Funding
- Dystonia Medical Research Foundation
- American Parkinson Disease Association
- United States Department of Defense [PR191874]
- National Institutes of Health [R56NS124764, NS108675]
- Parkinson's Foundation
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This review provides an overview of synaptic dysfunctions and neurochemical alterations in hyperkinetic movement disorders, including changes in synaptic plasticity and neuromodulation.
This review provides an overview of the synaptic dysfunctions of neuronal circuits and underlying neurochemical alterations observed in the hyperkinetic movement disorders, dystonia and dyskinesia. These disorders exhibit similar changes in expression of synaptic plasticity and neuromodulation. This includes alterations in physical attributes of synapses, synaptic protein expression, and neurotransmitter systems, such as glutamate and gammaaminobutyric acid (GABA), and neuromodulators, such as dopamine, acetylcholine, serotonin, adenosine, and endocannabinoids. A full understanding of the mechanisms and consequences of disruptions in synaptic function and plasticity will lend insight into the development of these disorders and new ways to combat maladaptive changes.
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