Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 29, Issue 4, Pages 283-286Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41594-022-00761-3
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Eukaryotes possess various clamp loaders, each with four common subunits and a unique fifth subunit. The RFC-A-E clamp loader loads the PCNA clamp at 3'-recessed DNA structures, while swapping the Rad24 subunit for RFC-A results in a loader that prefers the 911 clamp and 5'-recessed DNA. Recent studies provide detailed insights into the clamp loading reaction and substrate preferences of each loader.
Eukaryotes possess several clamp loaders comprising four common subunits and a fifth subunit unique to each complex. The RFC-A-E clamp loader loads the PCNA clamp at 3 '-recessed structures for DNA replication. However, swapping a single subunit, Rad24, for RFC-A yields a clamp loader that prefers the 911 clamp and 5 '-recessed DNA. Three new studies reveal detailed views of the clamp loading reaction and provide insights into substrate preferences of each loader.
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