Journal
NATURE REVIEWS NEUROLOGY
Volume 18, Issue 6, Pages 319-320Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41582-022-00650-9
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Single-cell transcriptomic analyses of human brain microvessels have identified transcriptomic signatures and transcriptional changes in the cerebrovasculature in neurodegenerative diseases, which could significantly contribute to our understanding of brain health and disease.
The mechanistic contribution of cerebrovascular dysfunction to neurodegenerative diseases is difficult to determine. New single-cell transcriptomic analyses of human brain microvessels have identified transcriptomic signatures along the arteriovenous axis and transcriptional changes in the cerebrovasculature in Alzheimer disease and Huntington disease. This approach could advance our understanding of brain health and disease.
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