Journal
NATURE REVIEWS ENDOCRINOLOGY
Volume 18, Issue 5, Pages 273-289Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41574-022-00641-2
Keywords
-
Categories
Funding
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH)
- NIH [R01DK098203, U01AR071133, HL150327-01A1, R01-HL138738, R01-AG060542, 1R01HL142879, U24DK112348, U54DK102556]
- Spanish Ministry of Economy and Competitiveness
- Fondos FEDER [PI18/00139]
- Occitanie Region/FEDER funds (DIABKINES) [MP0021755]
- TrygFonden for the Centre for PA Research (CFAS)
- Texas Health Resources Clinical Scholarship
- Gilead Sciences Research Scholar Program
- NIH National Institute of Aging GEMSSTAR grant [1R03AG067960-01]
- Applied Therapeutics
- NIH National Institute on Aging (NIA)/NIH IRP
- NIH National Institute on Aging (NIA)/NIH FDOH Ed
- Ethel Moore Alzheimer's Disease Research program
- National Institute for Health Research (NIHR) Leicester Biomedical Research Centre
- Swedish Research Council for Sport Science [P2018-0097]
- Swedish Research Council (Vetenskapsradet) [2015-00165]
- Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen [NNF18CC0034900]
- Occitanie Region/FEDER funds (Enterosys)
- European Federation of the Study of Diabetes/MSD
- Swedish Research Council [2015-00165] Funding Source: Swedish Research Council
Ask authors/readers for more resources
This Review summarizes the importance and current state of exerkine research, highlighting the potential roles of exerkines in improving cardiovascular, metabolic, immune, and neurological health. Exerkines are signaling molecules released during exercise, which have the potential for the treatment of cardiovascular disease, type 2 diabetes mellitus, obesity, and to facilitate healthy aging.
Exerkines are signalling moieties that are released in response to acute and/or chronic exercise that exert their effects through endocrine, paracrine and/or autocrine pathways. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions. The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardiovascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available