4.6 Review

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion

Related references

Note: Only part of the references are listed.
Article Oncology

Blinatumomab Nonresponse and High-Disease Burden Are Associated With Inferior Outcomes After CD19-CAR for B-ALL

Regina M. Myers et al.

Summary: This retrospective study investigates the impact of CD19-CAR therapy on relapsed or refractory ALL patients, revealing that nonresponse to blinatumomab and high disease burden are associated with worse survival outcomes.

JOURNAL OF CLINICAL ONCOLOGY (2022)

Article Hematology

Hematopoietic Cell Transplantation after CD19 Chimeric Antigen Receptor T Cell-Induced Acute Lymphoblastic Leukemia Remission Confers a Leukemia-Free Survival Advantage

Corinne Summers et al.

Summary: This study evaluated the effect of consolidative HCT on leukemia-free survival (LFS) in pediatric and young adult subjects following CD19 CART cell induced remission. The results showed that consolidative HCT improved LFS specifically in subjects who had no prior history of HCT and those with short functional CART cell persistence.

TRANSPLANTATION AND CELLULAR THERAPY (2022)

Article Hematology

Impact of Bridging Chemotherapy on Clinical Outcomes of CD19-Specific CAR T Cell Therapy in Children/Young Adults with Relapsed/Refractory B Cell Acute Lymphoblastic Leukemia

Sanam Shahid et al.

Summary: This study found that patients receiving >=2 cycles of bridging chemotherapy had higher rates of infection and lower overall survival, but no difference in CAR-T specific toxicity.

TRANSPLANTATION AND CELLULAR THERAPY (2022)

Article Hematology

Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies

Jordan Gauthier et al.

Summary: CD19 CAR T-cell therapy has shown significant efficacy for R/R B-cell malignancies, but durable responses are limited. Second infusions of CD19 CAR T cells (CART2) can improve outcomes, with positive therapeutic effects observed in CLL, NHL, and ALL patients after CART2.

BLOOD (2021)

Article Hematology

Earlier corticosteroid use for adverse event management in patients receiving axicabtagene ciloleucel for large B-cell lymphoma

Max S. Topp et al.

Summary: The study assessed the impact of early corticosteroid and tocilizumab use on cytokine release syndrome and neurologic events in patients with refractory large B-cell lymphoma receiving axi-cel therapy. Results indicate that early and planned use of these drugs may decrease the incidence of severe cytokine release syndrome and neurologic events.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Article Oncology

Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial

Stephan Kadauke et al.

Summary: The study evaluated the effectiveness of risk-adapted preemptive tocilizumab treatment in preventing severe cytokine release syndrome after CTL019 therapy, showing a decrease in the expected incidence of grade 4 CRS without impacting the antitumor efficacy of CTL019.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Use of cardiac radiation therapy as bridging therapy to CAR-T for relapsed pediatric B-cell acute lymphoblastic leukemia

Cesar P. Marquez et al.

Summary: This study presents a case of a boy with B-ALL who received successful bridging radiation therapy for cardiac and gastrointestinal involvement before CAR-T infusion, resulting in no disease recurrence during a 3-month follow-up. This is the first reported case of safe and effective delivery of cardiac radiation therapy in B-ALL.

PEDIATRIC BLOOD & CANCER (2021)

Article Hematology

Acute lymphoblastic leukemia: A population- based study of outcome in the United States based on the surveillance, epidemiology, and end results (SEER) database, 1980-2017

Koji Sasaki et al.

Summary: The treatment outcomes for patients with acute lymphoblastic leukemia (ALL) have significantly improved over the past four decades. Survival rates have increased across all age groups, with particularly notable improvements seen in children and adolescents. The introduction of targeted therapies and optimized supportive care have contributed to these advancements in patient outcomes.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Review Oncology

Unlocking the potential of antibody-drug conjugates for cancer therapy

Joshua Z. Drago et al.

Summary: Nine ADCs are currently approved for cancer treatment, with many more in development. Advances in synthetic biochemistry have led to a new generation of ADCs promising improved tissue specificity and cytotoxicity. Despite impressive activity against treatment-refractory cancers, challenges such as systemic toxicity and acquired resistance remain. This review discusses the design, mechanism of action, and limitations of ADCs, proposing strategies to maximize their therapeutic benefit for cancer patients.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Review Oncology

Immunogenicity of CAR T cells in cancer therapy

Dimitrios L. Wagner et al.

Summary: CAR T cells have shown significant clinical responses in patients with certain advanced-stage B cell malignancies, but some patients may experience anti-CAR immune responses leading to treatment failure. Strategies to monitor and reduce the risks of anti-CAR immune responses are needed to improve CAR T cell therapy outcomes.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Hematology

Combination of CD19 and CD22 CAR-T cell therapy in relapsed B-cell acute lymphoblastic leukemia after allogeneic transplantation

Shuangyou Liu et al.

Summary: The combination strategy of sequential CD19 and CD22 CAR-T therapy significantly improved the long-term survival in B-ALL patients who relapsed after transplantation, with high overall survival and event-free survival rates.

AMERICAN JOURNAL OF HEMATOLOGY (2021)

Article Oncology

Long-Term Follow-Up of CD19-CAR T-Cell Therapy in Children and Young Adults With B-ALL

Nirali N. Shah et al.

Summary: CD19-CAR T-cell therapy shows high response rates in CAYAs with B-ALL, but high relapse rates. Sequential therapy with CD19.28 zeta-CAR T cells followed by alloHSCT can achieve durable disease control in a sizable fraction of patients.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Glofitamab, a Novel, Bivalent CD20-Targeting T-Cell-Engaging Bispecific Antibody, Induces Durable Complete Remissions in Relapsed or Refractory B-Cell Lymphoma: A Phase I Trial

Martin Hutchings et al.

Summary: The study evaluated the use of glofitamab in relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) patients. The results showed favorable activity of glofitamab in patients with predominantly refractory, aggressive B-NHL, with frequent and durable complete responses and a predictable and manageable safety profile.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Hematology

Prophylactic corticosteroid use in patients receiving axicabtagene ciloleucel for large B-cell lymphoma

Olalekan O. Oluwole et al.

Summary: Prophylactic corticosteroids and earlier intervention with corticosteroids and/or tocilizumab resulted in a reduced rate of severe treatment-related toxicities and high response rates in patients with refractory large B-cell lymphoma. The majority of patients did not experience CRS or NEs within 72 hours of axi-cel treatment. Furthermore, 95% of patients achieved objective responses and 80% achieved complete responses in this study.

BRITISH JOURNAL OF HAEMATOLOGY (2021)

Review Oncology

Mechanisms of Therapeutic Antitumor Monoclonal Antibodies

Li-Chung Tsao et al.

Summary: Monoclonal antibodies are a crucial component of cancer therapy, primarily working by stimulating innate immune effector processes. Different therapeutic mAbs targeting various tumor antigens have shown significant efficacy, with a key role of innate immune-mediated mechanisms observed in mAb therapies against different types of cancer, including HER2(+) solid tumors.

CANCER RESEARCH (2021)

Review Oncology

Bispecific Immunomodulatory Antibodies for Cancer Immunotherapy

Belen Blanco et al.

Summary: Recent advances in immuno-oncology have led to a shift in therapeutic strategies for advanced malignancies, with bispecific antibody-based immunotherapies emerging as a promising new approach. These antibodies interact with immune cells to redirect and activate effector cells against tumor cells, potentially improving clinical efficacy and safety. Over 50 bispecific antibodies are currently in clinical development for various indications, showing signs of therapeutic activity, and new approaches for in vivo secretion are being explored for the application of next-generation bispecific immunomodulatory antibodies.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

Humanized CD19-Targeted Chimeric Antigen Receptor (CAR) T Cells in CAR-Naive and CAR-Exposed Children and Young Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia

Regina M. Myers et al.

Summary: In this study, huCART19 demonstrated high overall response rates in children and young adults with relapsed or refractory B-ALL, reaching 98% in the CAR-naive cohort and 100% in B-ALL patients. Despite common adverse events such as neurologic toxicities and cytokine release syndrome, these were mostly fully resolved, indicating durable remissions with long-term persistence achieved by huCART19.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Medicine, General & Internal

KTE-X19 for relapsed or refractory adult B-cell acute lymphoblastic leukaemia: phase 2 results of the single-arm, open-label, multicentre ZUMA-3 study

Bijal D. Shah et al.

Summary: KTE-X19 demonstrated a high rate of complete remission or complete remission with incomplete haematological recovery in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia. Median overall survival was not reached in responding patients, and the therapy showed a manageable safety profile. These findings suggest that KTE-X19 has the potential to provide long-term clinical benefit to these patients.

LANCET (2021)

Review Oncology

A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains

Kathryn M. Cappell et al.

Summary: CAR T cell therapies targeting haematological malignancies show promising efficacy, with CD28- and 4-1BB-derived costimulatory domains demonstrating potentially different cellular and clinical effects. Further research is needed to compare their effectiveness and toxicity profiles.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Hematology

Polatuzumab vedotin as a salvage and bridging treatment in relapsed or refractory large B-cell lymphomas

Nora Liebers et al.

Summary: The antibody-drug conjugate polatuzumab vedotin (pola) in combination with bendamustine and rituximab (pola-BR) has shown efficacy for patients with refractory or relapsed large B-cell lymphoma in a real-world setting. The treatment achieved encouraging overall response rates in salvage therapy and successfully bridged a significant number of patients to CAR T-cell therapy. These findings suggest that pola may serve as an effective salvage and bridging treatment option for patients with refractory or relapsed LBCL.

BLOOD ADVANCES (2021)

Review Oncology

Scalable Manufacturing of CAR T Cells for Cancer Immunotherapy

Mohamed Abou-el-Enein et al.

Summary: This review discusses the current status of commercially available CAR T cell therapies for hematologic malignancies and the shift towards Good Manufacturing Practice-compliant closed and automated systems in the industry. It also highlights the emerging technologic advances in CART cell manufacturing and the challenges in scaling production for clinical use. The review emphasizes the significance of closed and automated production platforms to meet the increasing demand for CAR T cell cancer therapy.

BLOOD CANCER DISCOVERY (2021)

Review Oncology

Recent advances and discoveries in the mechanisms and functions of CAR T cells

Rebecca C. Larson et al.

Summary: This review summarizes the major advances that have been made in the efficacy and safety of CAR T cell therapies over the past 3 years and looks ahead to new findings that will impact the future of this immunotherapy.

NATURE REVIEWS CANCER (2021)

Article Biochemistry & Molecular Biology

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

Jennifer N. Brudno et al.

NATURE MEDICINE (2020)

Article Oncology

Bridging Radiation Therapy Before Commercial Chimeric Antigen Receptor T-Cell Therapy for Relapsed or Refractory Aggressive B-Cell Lymphoma

Christopher M. Wright et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Hematology

Bilateral retinal detachment after chimeric antigen receptor T-cell therapy

Christopher C. Denton et al.

BLOOD ADVANCES (2020)

Article Oncology

Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

Kathryn M. Cappell et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Biochemistry & Molecular Biology

DNA damage response signaling pathways and targets for radiotherapy sensitization in cancer

Rui-Xue Huang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Review Oncology

Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy

Kris M. Mahadeo et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

Article Hematology

Tisagenlecleucel CAR T-cell therapy in secondary CNS lymphoma

Matthew J. Frigault et al.

BLOOD (2019)

Article Biotechnology & Applied Microbiology

Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T Cell Characteristics

Sandhya R. Panch et al.

MOLECULAR THERAPY (2019)

Article Cell Biology

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

Katrin Mestermann et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

Meeting Abstract Hematology

A Characterization of Bridging Therapies Leading up to Commercial CAR T-Cell Therapy

Sunita Dwivedy Nasta et al.

BLOOD (2019)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Hematology

Pharmacologic control of CAR-T cell function using dasatinib

Evan W. Weber et al.

BLOOD ADVANCES (2019)

Review Medicine, General & Internal

Chimeric Antigen Receptor Therapy

Carl H. June et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia

Jae H. Park et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Letter Oncology

Total Costs of Chimeric Antigen Receptor T-Cell Immunotherapy

Inmaculada Hernandez et al.

JAMA ONCOLOGY (2018)

Review Oncology

Tumor Antigen Escape from CAR T-cell Therapy

Robbie G. Majzner et al.

CANCER DISCOVERY (2018)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Cell & Tissue Engineering

Building blocks for institutional preparation of CTL019 delivery

Joseph McGuirk et al.

CYTOTHERAPY (2017)

Article Pharmacology & Pharmacy

Anti-CD22 and anti-CD79b antibody-drug conjugates preferentially target proliferating B cells

Franklin K. Fuh et al.

BRITISH JOURNAL OF PHARMACOLOGY (2017)

Review Medicine, Research & Experimental

CAR-T Cell Therapy for Lymphoma

Carlos A. Ramos et al.

ANNUAL REVIEW OF MEDICINE, VOL 67 (2016)

Article Medicine, Research & Experimental

CD19 CAR-T cells of defined CD4+: CD8+ composition in adult B cell ALL patients

Cameron J. Turtle et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Medicine, General & Internal

Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia

John C. Byrd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

Hagop M. Kantarjian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Review Hematology

CAR-T Cell Therapies From the Transfusion Medicine Perspective

Andrew Fesnak et al.

TRANSFUSION MEDICINE REVIEWS (2016)

Review Genetics & Heredity

The Cell Killing Mechanisms of Hydroxyurea

Amanpreet Singh et al.

GENES (2016)

Review Oncology

Childhood Acute Lymphoblastic Leukemia: Progress Through Collaboration

Ching-Hon Pui et al.

JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Multidisciplinary Sciences

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

Christina Twyman-Saint Victor et al.

NATURE (2015)

Review Oncology

Opportunities and challenges of radiotherapy for treating cancer

Doerthe Schaue et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2015)

Article Cell Biology

Anti-CD20/CD3 T cell-dependent bispecific antibody for the treatment of B cell malignancies

Liping L. Sun et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Review Oncology

Diffuse large B-cell lymphoma

Maurizio Martelli et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2013)

Editorial Material Oncology

Asparaginases: A Successful Class of Drugs Against Leukemias and Lymphomas

Vassilios I. Avramis

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2011)

Review Oncology

Cyclophosphamide and cancer: golden anniversary

Ashkan Emadi et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2009)

Review Oncology

Targeting DNA topoisomerase II in cancer chemotherapy

John L. Nitiss

NATURE REVIEWS CANCER (2009)

Article Oncology

Timeline - Chemotherapy and the war on cancer

BA Chabner et al.

NATURE REVIEWS CANCER (2005)