Journal
NATURE METHODS
Volume 19, Issue 4, Pages 374-380Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41592-022-01444-z
Keywords
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Categories
Funding
- National Science Foundation [2041984]
- NSFC Excellent Young Scientists Fund (Hong Kong and Macau) [31922087]
- Research Grants Council (RGC) Collaborative Research Fund [C7144-20GF]
- RGC Research Impact Fund [R7021-20]
- Innovation and Technology Commission's InnoHK [D24H]
- Health and Medical Research Fund [COVID190223]
- US National Institutes of Health (NIH) [1R01EB025022]
- National Science Foundation (NSF) [2047828]
- King Abdulaziz City for Science and Technology
- Saudi Human Genome Project
- US NIH [R00 AI139445, DP2 AT011966, R01 AI167910]
- NSF [2029025, 2038509]
- NIH [1R01EB025022-01, 1R21CA241044-01A1, R01 HG009120, R01 MH115676, R01 AI153827, U01 HG011715, R33AI12945, R01 AI153044, U19 AI135995]
- Molecular Basis of Disease at Georgia State University
- CAMS Innovation Fund for Medical Sciences [2021-I2M-1-061]
- CDC [30055281]
- NIH-National Institute of Allergy and Infectious Diseases (NIAID) [R01 AI135992]
- Branco Weiss Fellowship
- Ministry of Science and Higher Education of the Russian Federation [075-15-2020-926]
- US National Institute of General Medical Sciences IDeA Alaska INBRE [P20GM103395]
- NIAID CEIRR [75N93019R00028]
- Testing for America [501c3]
- OpenCovidScreen Foundation
- Igor Tulchinsky
- WorldQuant Foundation
- Pershing Square Foundation
- Ken Griffin and Citadel
- US National Institutes of Health [R01AI125416, R01AI151059, R21AI129851, U01DA053941]
- Alfred P. Sloan Foundation [G-2015-13964]
- US CDC Epidemiology and Laboratory Capacity (ELC) [6NU50CK000539]
- US CDC [75D30121C10991]
- RFBR [20-515-80017]
- European Research Council (ERC) under the European Union [similar to725422]
- Wellcome Trust [206298/Z/17/Z]
- US NSF [EEID-IOS-2109688]
- ERC [771209]
- European Research Council (ERC) [771209] Funding Source: European Research Council (ERC)
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [2047828] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [2041984, 2038509] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [2029025] Funding Source: National Science Foundation
Ask authors/readers for more resources
During the COVID-19 pandemic, genomics and bioinformatics have become crucial tools in public health. They have been used to acquire genomic data that support global health responses, aid in the development of testing methods, and enable the timely tracking of novel SARS-CoV-2 variants. However, the rapid generation and analysis of genomic data present unique technical, scientific, and organizational challenges.
During the COVID-19 pandemic, genomics and bioinformatics have emerged as essential public health tools. The genomic data acquired using these methods have supported the global health response, facilitated the development of testing methods and allowed the timely tracking of novel SARS-CoV-2 variants. Yet the virtually unlimited potential for rapid generation and analysis of genomic data is also coupled with unique technical, scientific and organizational challenges. Here, we discuss the application of genomic and computational methods for efficient data-driven COVID-19 response, the advantages of the democratization of viral sequencing around the world and the challenges associated with viral genome data collection and processing.
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