Journal
NATURE IMMUNOLOGY
Volume 23, Issue 5, Pages 649-651Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41590-022-01196-0
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LAG3 interferes with TCR signaling by lowering pH and inducing dissociation of Lck from CD8 and CD4 co-receptors.
LAG3 interferes with TCR signaling by lowering the pH in the vicinity of the TCR and inducing dissociation of the key signaling kinase Lck from the co-receptors CD8 and CD4.
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