4.8 Article

Nonlinear mechanics of human mitotic chromosomes

Related references

Note: Only part of the references are listed.
Review Cell Biology

Mitotic chromosomes

James R. Paulson et al.

Summary: Our understanding of the structure and function of mitotic chromosomes has significantly progressed over the years, with key non-histone proteins and protein complexes playing important roles in chromosome formation. Condensins I and II shape the chromosome and scaffold through an ATP-dependent process called loop extrusion, ultimately compacting the mitotic chromosome with the help of Topo II alpha.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Article Multidisciplinary Sciences

Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly

Keishi Shintomi et al.

Summary: Topoisomerase II alpha plays a crucial role in mitotic chromatid assembly. By refining the mitotic chromatid reconstitution assay, researchers have gained new insights into the C-terminal domain (CTD) of topo II alpha. The CTD contributes to proper formation of nucleosome-depleted chromatids and fine-tunes the enzymatic core delivery process during mitotic chromatid assembly.

NATURE COMMUNICATIONS (2021)

Review Biophysics

The mechanics of mitotic chromosomes

T. Man et al.

Summary: Condensation and faithful separation of the genome are essential for the cellular life cycle, and mechanical properties of mitotic chromosomes remain a topic of interest. Recent advances in genomics and microscopy techniques have improved understanding of chromosomal structure, leading to a focus on mechanical characteristics and their relationship to chromosome structure.

QUARTERLY REVIEWS OF BIOPHYSICS (2021)

Article Biology

HP1α is a chromatin crosslinker that controls nuclear and mitotic chromosome mechanics

Amy R. Strom et al.

Summary: HP1 alpha plays a critical role in chromatin-based mechanics by maintaining chromatin stiffness and nuclear morphology, supporting cellular functions.

ELIFE (2021)

Article Multidisciplinary Sciences

Topoisomerase IIα is essential for maintenance of mitotic chromosome structure

Christian F. Nielsen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

A pathway for mitotic chromosome formation

Johan H. Gibcus et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Condensin controls mitotic chromosome stiffness and stability without forming a structurally contiguous scaffold

Mingxuan Sun et al.

CHROMOSOME RESEARCH (2018)

Article Multidisciplinary Sciences

An intrinsic S/G2 checkpoint enforced by ATR

Joshua C. Saldivar et al.

SCIENCE (2018)

Review Biochemistry & Molecular Biology

A Topology-Centric View on Mitotic Chromosome Architecture

Ewa Piskadlo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Multidisciplinary Sciences

Chromosome biorientation produces hundreds of piconewtons at a metazoan kinetochore

Anna A. Ye et al.

NATURE COMMUNICATIONS (2016)

Review Chemistry, Multidisciplinary

Optical Tweezers Analysis of DNA-Protein Complexes

Iddo Heller et al.

CHEMICAL REVIEWS (2014)

Article Biochemistry & Molecular Biology

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells

Christine J. Farr et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Physics, Multidisciplinary

Modeling semiflexible polymer networks

C. P. Broedersz et al.

REVIEWS OF MODERN PHYSICS (2014)

Article Biochemical Research Methods

STED nanoscopy combined with optical tweezers reveals protein dynamics on densely covered DNA

Iddo Heller et al.

NATURE METHODS (2013)

Article Chemistry, Multidisciplinary

Binding-Activated Localization Microscopy of DNA Structures

Ingmar Schoen et al.

NANO LETTERS (2011)

Article Biochemistry & Molecular Biology

Micromechanics of human mitotic chromosomes

Mingxuan Sun et al.

PHYSICAL BIOLOGY (2011)

Article Chemistry, Physical

Measurement of nonlinear rheology of cross-linked biopolymer gels

Chase P. Broedersz et al.

SOFT MATTER (2010)

Article Biochemistry & Molecular Biology

Studying vertebrate topoisomerase 2 function using a conditional knockdown system in DT40 cells

Mark Johnson et al.

NUCLEIC ACIDS RESEARCH (2009)

Review Biochemical Research Methods

Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy

Keir C. Neuman et al.

NATURE METHODS (2008)

Article Multidisciplinary Sciences

Glass transition and rheological redundancy in F-actin solutions

Christine Semmrich et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Physics, Multidisciplinary

Cross-linker unbinding and self-similarity in bundled cytoskeletal networks

O. Lieleg et al.

PHYSICAL REVIEW LETTERS (2007)

Article Multidisciplinary Sciences

Elastic Behavior of cross-linked and bundled actin networks

ML Gardel et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

Reversible hypercondensation and decondensation of mitotic chromosomes studied using combined chemical-micromechanical techniques

MG Poirier et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2002)

Article Cell Biology

Reversible and irreversible unfolding of mitotic newt chromosomes by applied force

M Poirier et al.

MOLECULAR BIOLOGY OF THE CELL (2000)