Journal
NATURE
Volume 604, Issue 7904, Pages 47-48Publisher
NATURE PORTFOLIO
DOI: 10.1038/d41586-022-00870-5
Keywords
Molecular biology; Biological techniques; Genetics; Biophysics
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An integrated technique is introduced to quantify and disentangle the effects of gene mutations on protein traits, allowing assessments of mutational effects on protein biophysics.
An integrated technique that quantifies allosteric effects. A general method that quantifies and disentangles the effects of a gene's mutations on the traits of its protein enables assessments of mutational effects on protein biophysics for many of the proteins of a living organism.
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