4.4 Article

Water soluble microparticles of Sambucus nigra L. (elderberry) as a potential herbal medicine

Journal

NATURAL PRODUCT RESEARCH
Volume 36, Issue 23, Pages 6116-6120

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2053967

Keywords

Dried extract; spray drying; stability; water soluble microparticles; flavonoids

Funding

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88887.122964/2016-00, 001]
  2. Conselho Nacional de Pesquisa e Tecnologia (CNPq) [444682/2014-7, 483577/2013-8]
  3. FAPESC [2019TR147]

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In this study, spray dried microparticles of elderberry flowers were developed using optimized drying conditions and formulation, which improved their stability and ease of application.
Although traditional use of elderberry flowers is recognized by Medical Agencies, there are not suitable products on the Brazilian market. To overcome poor stability of tinctures of Sambucus nigra flowers, we aimed to develop spray dried microparticles. Statistical experimental design was applied taking inlet temperature and maltodextrin% at five different levels. Next, we applied a stability study for 60 days under accelerated conditions (40 degrees C/75% RH) and 180 days at room temperature (15-30 degrees C). We monitored flavonoid content as markers. The best drying condition was 188 degrees C and 65% of carrier and enabled microparticles with more than 90% of markers recovery. After 180 days, the dried extract remained with 90.8% at room temperature. The markers were released from microparticles in two minutes. In conclusion, the spray drying process and formulation enabled elderberry flowers to be easier to apply in solid pharmaceutical forms.

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