Journal
JOURNAL OF ANTIBIOTICS
Volume 70, Issue 4, Pages 378-385Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ja.2016.136
Keywords
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Funding
- Joint BioEnergy Institute - Office of Science, Office of Biological and Environmental Research of the US Department of Energy [DE-ACO2-05CH11231]
- Department of Energy, ARPA-E Electrofuels Program [DE-0000206-1577]
- National Science Foundation [EEC-0540879]
- Synthetic Biology Engineering Research Center, Award [MCB-1341894]
- Graduate Research Fellowship Program [DGE 1106400, 1106400]
- NNF Center for Biosustainability [Yeast Cell Factories, Synthetic Biology Tools for Yeast] Funding Source: researchfish
- Novo Nordisk Fonden [NNF10CC1016517] Funding Source: researchfish
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Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.
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