Journal
NANO LETTERS
Volume 22, Issue 11, Pages 4376-4382Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.2c00819
Keywords
Type 1 diabetes; artificial antigen presenting cells; auto reactive T-cells; Layer-by-layer particles
Categories
Funding
- EMBO
- Rosetrees Trust
- Oxford-UCB fellowship
- Wellcome [PRF 100262Z/12/Z]
- Kennedy Trust for Rheumatology Research
- Human Frontiers Science Program
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The study develops a unique artificial antigen-presenting cell system that can detect and target autoreactive T-cell populations, providing a promising tool for preventing autoimmune diseases.
Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingredients. Using our aAPC, we demonstrate that we are able to detect rare autoreactive CD4 populations in human patients, and using mouse models, we demonstrate that our particles are able to induce desensitization in the autoreactive population. This system provides a promising tool that can be used in the prevention of autoimmunity before disease onset.
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