Aminophenol-Decorated Gold Nanoparticles for Curing Bacterial Infections

Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those ofconventional antibiotics. This situation may hinder the developmentof novel nanoscale antibiotics. Here, we present aminophenol (AP) tomodify gold nanoparticles (AP_Au NPs) which show a broadantibacterial spectrum and potent antibacterial effects againstmultidrug-resistant (MDR) bacteria with clear antibacterial mecha-nisms. AP_Au NPs can not only damage bacterial cell walls but alsobind to the 16S rRNA to block bacterial protein synthesis. Moreover,AP_Au NPs show excellent performance in curing abdominalbacterial infections in anin vivomodel. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications

Automated summary

This study presents the modification of gold nanoparticles with aminophenol, which demonstrates a broad spectrum of antibacterial effects and strong efficacy against multidrug-resistant bacteria. The mechanisms of action include damaging bacterial cell walls and inhibiting bacterial protein synthesis. In vivo experiments also show promising results in treating abdominal bacterial infections.