Diversity of biologically active secondary metabolites in the ascomycete order Sordariales

Ascomycetes belonging to the order Sordariales are a well-known reservoir of secondary metabolites with potential beneficial applications. Species of the Sordariales are ubiquitous, and they are commonly found in soils and in lignicolous, herbicolous, and coprophilous habitats. Some of their species have been used as model organisms in modern fungal biology or were found to be prolific producers of potentially useful secondary metabolites. However, the majority of sordarialean species are poorly studied. Traditionally, the classification of the Sordariales has been mainly based on morphology of the ascomata, ascospores, and asexual states, characters that have been demonstrated to be homoplastic by modern taxonomic studies based on multi-locus phylogeny. Herein, we summarize for the first time relevant information about the available knowledge on the secondary metabolites and the biological activities exerted by representatives of this fungal order, as well as a current outlook of the potential opportunities that the recent advances in omic tools could bring for the discovery of secondary metabolites in this order.

Automated summary

Sordariales order of ascomycetes are known for their potential beneficial secondary metabolites, but most species remain poorly studied. Traditional classification is based on morphology, which has been shown to be homoplastic by modern multi-locus phylogeny studies.