Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 28, Issue 11, Pages 1819-1824Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/13524585221079533
Keywords
Multiple sclerosis; demyelinating disease; gut microbiota; stability; paediatric; monophasic acquired demyelinating syndrome
Categories
Funding
- Multiple Sclerosis Scientific and Research Foundation [EGID: 2636]
- Foundation of the Consortium of Multiple Sclerosis Centers' MS Workforce of the Future program
- University of British Columbia Faculty of Medicine Summer Student Research Program
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This study examined the changes in gut microbiota composition across repeated samples in paediatric-onset multiple sclerosis (MS) and monophasic-acquired demyelinating syndromes (monoADS). The results showed stability in microbiota composition between different stool samples, suggesting that single stool sample procurement is a reasonable first approach.
Objective: Examine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS). Methods: A total of 36 individuals (18 MS/18 monoADS) with > 2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed. Results: Mean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus - Solobacterium did (p = 0.001). Conclusions: The gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach.
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