4.6 Article

Solubility and Permeability Enhancement of Oleanolic Acid by Solid Dispersion in Poloxamers and γ-CD

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Development and Characterization of Eudragit® EPO-Based Solid Dispersion of Rosuvastatin Calcium to Foresee the Impact on Solubility, Dissolution and Antihyperlipidemic Activity

Sana Inam et al.

Summary: This study investigated the effect of a pH-sensitive acrylate polymer, EPO, on the physicochemical properties of rosuvastatin calcium, with preparation of solid dispersions showing increased solubility and drug release, leading to optimized formulations with significant improvements in solubility and drug release for RoC.

PHARMACEUTICALS (2022)

Article Multidisciplinary Sciences

Preparation of solid dispersion systems for enhanced dissolution of poorly water soluble diacerein: In-vitro evaluation, optimization and physiologically based pharmacokinetic modeling

Shahinaze A. Fouad et al.

Summary: Solid dispersion systems of DCN were prepared to improve solubility and bioavailability, with optimization using I-Optimal factorial design. PBPK modeling was utilized to predict the oral bio-performance of DCN, demonstrating the utility of PBPK in formulation development of BCS II APIs.

PLOS ONE (2021)

Article Pharmacology & Pharmacy

How Does the Addition of Kollidon(R)VA64 Inhibit the Recrystallization and Improve Ezetimibe Dissolution from Amorphous Solid Dispersions?

Joanna Szafraniec-Szczesny et al.

Summary: Amorphization can enhance the dissolution of drug compounds, and studying the stability of amorphous solid dispersions is necessary. This study investigated the effect of PVP/VA content on the physical stability and dissolution characteristics of ezetimibe, finding that a low polymer concentration can lead to fully amorphous systems and significant dissolution enhancement.

PHARMACEUTICS (2021)

Article Biochemistry & Molecular Biology

Preparation, Characterization, and Bioavailability of Host-Guest Inclusion Complex of Ginsenoside Re with Gamma-Cyclodextrin

Hui Li et al.

Summary: This study successfully improved the water solubility and bioavailability of Ginsenoside G-Re by forming an inclusion complex with gamma-CD. The results demonstrated that gamma-CD was a suitable inclusion host for enhancing the solubility and bioavailability of G-Re.

MOLECULES (2021)

Article Polymer Science

Enhanced Dissolution of Sildenafil Citrate Using Solid Dispersion with Hydrophilic Polymers: Physicochemical Characterization and In Vivo Sexual Behavior Studies in Male Rats

Mohammed F. Aldawsari et al.

Summary: Sildenafil citrate (SLC) is a commonly used medication for erectile dysfunction (ED), but its poor solubility limits its effectiveness. By preparing and evaluating solid dispersions (SDs) with hydrophilic polymers, especially SLC-KVA64, this study found significant improvements in dissolution and efficacy in male rats, indicating a potential strategy for enhancing the therapeutic efficacy of SLC.

POLYMERS (2021)

Article Pharmacology & Pharmacy

Preparation and evaluation of a novel solid dispersion using leucine as carrier

Xiaojing Xia et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Overview of Extensively Employed Polymeric Carriers in Solid Dispersion Technology

Athira R. Nair et al.

AAPS PHARMSCITECH (2020)

Article Pharmacology & Pharmacy

Development and Characterization of Spray-dried Amorphous Solid Dispersion of Sildenafil: In vivo Evaluation

Mohammed Muqtader Ahmed et al.

INTERNATIONAL JOURNAL OF PHARMACOLOGY (2020)

Article Biochemistry & Molecular Biology

Formulation of Nanomicelles to Improve the Solubility and the Oral Absorption of Silymarin

Vieri Piazzini et al.

MOLECULES (2019)

Article Pharmacology & Pharmacy

Multicomponent solid dispersion as a formulation strategy to improve drug permeation: A case study on the anti-colorectal cancer irinotecan

Laura Modica De Mohac et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

Article Chemistry, Medicinal

Effects of Surfactants on Itraconazole-HPMCAS Solid Dispersion Prepared by Hot-Melt Extrusion I: Miscibility and Drug Release

Nayan G. Solanki et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Article Pharmacology & Pharmacy

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques

Sultan M. Alshehri et al.

SAUDI PHARMACEUTICAL JOURNAL (2019)

Review Biochemistry & Molecular Biology

Oleanolic Acid and Its Derivatives: Biological Activities and Therapeutic Potential in Chronic Diseases

Taiwo Betty Ayeleso et al.

MOLECULES (2017)

Article Pharmacology & Pharmacy

Application of hot melt extrusion to enhance the dissolution and oral bioavailability of oleanolic acid

Nannan Gao et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

Article Chemistry, Medicinal

Study of a novel disintegrable oleanolic acid-polyvinylpolypyrrolidone solid dispersion

Weiqin Wang et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2017)

Review Pharmacology & Pharmacy

Amorphous solid dispersions: Rational selection of a manufacturing process

Teofilo Vasconcelos et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Article Pharmacology & Pharmacy

Nimesulide-loaded nanoparticles for the potential coadjuvant treatment of prostate cancer

Concepcion Huerta et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

Review Pharmacology & Pharmacy

Fundamental aspects of solid dispersion technology for poorly soluble drugs

Yanbin Huang et al.

ACTA PHARMACEUTICA SINICA B (2014)

Article Biochemistry & Molecular Biology

Efficient Synthesis and Anti-Fungal Activity of Oleanolic Acid Oxime Esters

Hanqing Zhao et al.

MOLECULES (2013)

Article Biochemistry & Molecular Biology

Oleanolic acid

Jacob Pollier et al.

PHYTOCHEMISTRY (2012)

Article Agriculture, Multidisciplinary

Pentacyclic Triterpenoids from Olive Fruit and Leaf

Angeles Guinda et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Phase behaviour of oleanolic acid/stearyl stearate binary mixtures in bulk and at the air-water interface

Ana C. T. Teixeira et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2009)

Article Pharmacology & Pharmacy

Proliposomes of exemestane for improved oral delivery: Formulation and in vitro evaluation using PAMPA, Caco-2 and rat intestine

Praveen S. Hiremath et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2009)

Article Chemistry, Multidisciplinary

A novel design of artificial membrane for improving the PAMPA model

Xiaoxi Chen et al.

PHARMACEUTICAL RESEARCH (2008)

Article Pharmacology & Pharmacy

Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats

Dong Won Jeong et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2007)

Article Pharmacology & Pharmacy

Oleanolic acid nanosuspensions: preparation, in-vitro characterization and enhanced hepatoprotective effect

YJ Chen et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2005)

Article Food Science & Technology

Supplementation of oils with oleanolic acid from the olive leaf (olea europaea)

A Guinda et al.

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY (2004)