Journal
MOLECULES
Volume 27, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules27062012
Keywords
nimodipine; inclusion complexes; hydroxypropyl-beta-cyclodextrin; methyl-beta-cyclodextrin; orally disintegrating tablets
Funding
- Carol Davila University of Medicine and Pharmacy
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The aim of this study was to manufacture new orally disintegrating tablets containing nimodipine-hydroxypropyl-beta-cyclodextrin and nimodipine-methyl-beta-cyclodextrin inclusion complexes. Three methods of preparation were compared, and the lyophilization method was found to be more effective. The formulation and precompression studies for the tablets containing the inclusion complexes were successfully assessed.
The aim of the present study was to manufacture new orally disintegrating tablets containing nimodipine-hydroxypropyl-beta-cyclodextrin and nimodipine-methyl-beta-cyclodextrin inclusion complexes. For obtaining a better quality of the manufactured tablets, three methods of the preparation of inclusion complexes, in a 1:1 molar ratio, were used comparatively; namely, a solid-state kneading method and two liquid state coprecipitation and lyophilization techniques. The physical and chemical properties of the obtained inclusion complexes, as well as their physical mixtures, were investigated using Fourier transformed infrared spectroscopy, scanning electron microscopy, X-ray diffraction analyses, and differential scanning calorimetry. The results showed that the lyophilization method can be successfully used for a better complexation. Finally, the formulation and precompression studies for tablets for oral dispersion, containing Nim-HP-beta-CD and Nim-Me-beta-CD inclusion complexes, were successfully assessed.
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