Journal
MOLECULES
Volume 27, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/molecules27061966
Keywords
hydroxypyridinones; chelating agents; metal chelators; ecotoxicity remediation; luminescent probes
Funding
- FundacAo para a Ciencia e Tecnologia (FCT) [UIDB/00100/2020, UIDP/00100/2020, LA/P/0056/2020]
- COST (European Cooperation in Science and Technology) [CA18202]
- COST Action [CA18202]
Ask authors/readers for more resources
Hydroxypyridinones (HPs) are versatile chemical tools for engineering metal chelating agents with high affinity for hard metal ions. This review focuses on recent works that utilize hydroxypyridinone-based ligands for environmental applications, specifically the remediation of hard metal ion ecotoxicity. The article outlines the design of new chelating systems and analyzes the relationship between ligand structures and activities, including metal affinity and thermodynamic stability of metal complexes.
Hydroxypyridinones (HPs) are recognized as excellent chemical tools for engineering a diversity of metal chelating agents, with high affinity for hard metal ions, exhibiting a broad range of activities and applications, namely in medical, biological and environmental contexts. They are easily made and functionalizable towards the tuning of their pharmacokinetic properties or the improving of their metal complex thermodynamic stabilities. In this review, an analysis of the recently published works on hydroxypyridinone-based ligands, that have been mostly addressed for environmental applications, namely for remediation of hard metal ion ecotoxicity in living beings and other biological matrices is carried out. In particular, herein the most recent developments in the design of new chelating systems, from bidentate mono-HP to polydentate multi-HP derivatives, with a structural diversity of soluble or solid-supported backbones are outlined. Along with the ligand design, an analysis of the relationship between their structures and activities is presented and discussed, namely associated with the metal affinity and the thermodynamic stability of the corresponding metal complexes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available