4.6 Review

Role of Intracellular Iron in Switching Apoptosis to Ferroptosis to Target Therapy-Resistant Cancer Stem Cells

Related references

Note: Only part of the references are listed.
Review Cell Biology

Targeting Cell Death: Pyroptosis, Ferroptosis, Apoptosis and Necroptosis in Osteoarthritis

Jian Yang et al.

Summary: New research has shown that the development of osteoarthritis is influenced by different mechanisms of cell death and types of cytokines. Understanding the interaction between cytokines, cell death processes, and osteoarthritis is crucial for better understanding the pathogenesis and progression of the disease.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Review Cell Biology

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

Pranavi Koppula et al.

Summary: The overexpression of SLC7A11 promotes tumor growth while causing significant metabolic reprogramming costs for cancer cells. Cancer cells with high expression of SLC7A11 exhibit glucose- and glutamine-dependency, presenting potential metabolic vulnerabilities for therapeutic targeting.

PROTEIN & CELL (2021)

Article Pharmacology & Pharmacy

Targeting CD166+ lung cancer stem cells: Molecular study using murine dendritic cell vaccine

N. E. El-Ashmawy et al.

Summary: The dendritic cell vaccine loaded with tumor cell lysate (TCL-DCV) can ameliorate lung cancer stemness by modulating immune responses, making it a promising therapeutic alternative for chemotherapy resistant cases.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

The central role of glutathione peroxidase 4 in the regulation of ferroptosis and its implications for pro-inflammatory cytokine-mediated beta-cell death

Bastian Kruemmel et al.

Summary: Pro-inflammatory cytokines play a crucial role in beta-cell destruction in type 1 diabetes mellitus, while the involvement of ferroptosis in the pathogenesis of the disease has not been clearly defined. The antioxidative enzyme GPx4 is predominantly expressed in beta-cells, and its overexpression as well as the ferroptosis inhibitor ferrostatin-1 can effectively attenuate beta-cell death. Nitric oxide produced during pro-inflammatory cytokine action prevents the induction of ferroptosis, favoring apoptosis as the primary cell death mechanism in beta-cells.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Review Oncology

Ferroptosis in Cancer Cell Biology

Christina M. Bebber et al.

CANCERS (2020)

Review Oncology

The role of autophagy in resistance to targeted therapies

Luigi Mele et al.

CANCER TREATMENT REVIEWS (2020)

Article Biochemistry & Molecular Biology

xCT (SLC7A11) expression confers intrinsic resistance to physical plasma treatment in tumor cells

Sander Bekeschus et al.

REDOX BIOLOGY (2020)

Article Multidisciplinary Sciences

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Michael A. Badgley et al.

SCIENCE (2020)

Article Pharmacology & Pharmacy

Targeting SLC7A11 specifically suppresses the progression of colorectal cancer stem cells via inducing ferroptosis

Xiaotian Xu et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2020)

Article Cell & Tissue Engineering

Glutathione metabolism is essential for self-renewal and chemoresistance of pancreatic cancer stem cells

Petra Jagust et al.

WORLD JOURNAL OF STEM CELLS (2020)

Review Oncology

Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance

Sara M. Elgendy et al.

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2020)

Review Biochemistry & Molecular Biology

Ferroptosis and necroinflammation, a yet poorly explored link

Bettina Proneth et al.

CELL DEATH AND DIFFERENTIATION (2019)

Review Biochemistry & Molecular Biology

Dysregulation of iron metabolism in cancer stem cells

Stefania Recalcati et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Review Genetics & Heredity

Cancer stem cells: A brief review of the current status

Alican Kusoglu et al.

Review Biochemistry & Molecular Biology

Regulation of Gene Expression under Hypoxic Conditions

Koh Nakayama et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Iron and lung cancer

Yanbin Kuang et al.

CANCER LETTERS (2019)

Review Biochemistry & Molecular Biology

Iron Metabolism in Cancer

Yafang Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

Ferroptosis at the crossroads of cancer-acquired drug resistance and immune evasion

Jose Pedro Friedmann Angeli et al.

NATURE REVIEWS CANCER (2019)

Review Oncology

Exosomal tetraspanins as regulators of cancer progression and metastasis and novel diagnostic markers

Rama Rao Malla et al.

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2018)

Article Oncology

Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis

Ling-Chu Chang et al.

CANCER LETTERS (2018)

Article Medicine, Research & Experimental

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Oncology

The biology and role of CD44 in cancer progression: therapeutic implications

Chen Chen et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Biochemistry & Molecular Biology

CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells

Sayo Horibe et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Pharmacology & Pharmacy

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

Xinbing Sui et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Oncology

The role of CD133 in cancer: a concise review

Paige M. Glumac et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2018)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Cancer stem cells revisited

Eduard Batlle et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

Iron addiction: a novel therapeutic target in ovarian cancer

D. Basuli et al.

ONCOGENE (2017)

Article Multidisciplinary Sciences

Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells

Chiara Raggi et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Biochemistry & Molecular Biology

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

Rachel P. Abrams et al.

ACS CHEMICAL BIOLOGY (2016)

Article Cell Biology

Ferroptosis is an autophagic cell death process

Minghui Gao et al.

CELL RESEARCH (2016)

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Review Cell & Tissue Engineering

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy

Wanyin Chen et al.

STEM CELLS INTERNATIONAL (2016)

Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

Review Medicine, Research & Experimental

CD26 a cancer stem cell marker and therapeutic target

Samuel Davies et al.

BIOMEDICINE & PHARMACOTHERAPY (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Multidisciplinary Sciences

CD271+ Osteosarcoma Cells Display Stem-Like Properties

Jiguang Tian et al.

PLOS ONE (2014)

Editorial Material Biochemistry & Molecular Biology

The essential nature of iron usage and regulation

Jerry Kaplan et al.

CURRENT BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Molecular docking and dynamics simulations of A.niger RNase from Aspergillus niger ATCC26550: for potential prevention of human cancer

Gundampati Ravi Kumar et al.

JOURNAL OF MOLECULAR MODELING (2013)

Review Oncology

Iron and cancer: more ore to be mined

Suzy V. Torti et al.

NATURE REVIEWS CANCER (2013)

Article Medicine, Research & Experimental

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

Rhonda L. Brown et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Pharmacology & Pharmacy

Apoptosis and cancer stem cells: Implications for apoptosis targeted therapy

Frank A. E. Kruyt et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Review Biochemistry & Molecular Biology

Two to Tango: Regulation of Mammalian Iron Metabolism

Matthias W. Hentze et al.

Review Oncology

Cancer stem cells in solid tumors

Patrick C. Hermann et al.

SEMINARS IN CANCER BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Identification and targeting of cancer stem cells

Tobias Schatton et al.

BIOESSAYS (2009)

Article Cell Biology

The Stem Cell Marker CD133 (Prominin-1) Is Expressed in Various Human Glandular Epithelia

Jana Karbanova et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2008)

Review Cell Biology

Tuning cell cycle regulation with an iron key

Yu Yu et al.

CELL CYCLE (2007)

Review Pathology

Apoptosis: A review of programmed cell death

Susan Elmore

TOXICOLOGIC PATHOLOGY (2007)

Article Biochemistry & Molecular Biology

Analysis of gene expression and chemoresistance of CDI33+ cancer stem cells in glioblastoma

Gentao Liu et al.

MOLECULAR CANCER (2006)

Review Oncology

Tumour stem cells and drug resistance

M Dean et al.

NATURE REVIEWS CANCER (2005)