Copper-Free Halodediazoniation of Arenediazonium Tetrafluoroborates in Deep Eutectic Solvents-like Mixtures

Deep Eutectic Solvent (DES)-like mixtures, based on glycerol and different halide organic and inorganic salts, are successfully exploited as new media in copper-free halodediazoniation of arenediazonium salts. The reactions are carried out in absence of metal-based catalysts, at room temperature and in a short time. Pure target products are obtained without the need for chromatographic separation. The solvents are fully characterized, and a computational study is presented aiming to understand the reaction mechanism.

Automated summary

Deep eutectic solvent (DES)-like mixtures based on glycerol and different halide organic and inorganic salts have been successfully used as new media for copper-free halodediazoniation of arenediazonium salts. The reactions are conducted without the need for metal-based catalysts, at room temperature, and in a short period of time. Pure target products are obtained without the requirement of chromatographic separation. The solvents have been fully characterized and a computational study has been presented in order to understand the reaction mechanism.