Journal
MOLECULES
Volume 27, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules27103293
Keywords
N-dealkylation; opiate alkaloids; drug metabolite; tropane alkaloids
Funding
- Open Technology Programme of Toegepaste en Technische Wetenschappen (TTW) [15230]
- Netherlands Organisation for Scientific Research (NWO)
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N-dealkylation is an important chemical transformation for the synthesis of pharmaceuticals and chemicals, as well as a crucial metabolic pathway in vivo. The identification and synthesis of drug metabolites has significant implications in drug development studies.
N-dealkylation, the removal of an N-alkyl group from an amine, is an important chemical transformation which provides routes for the synthesis of a wide range of pharmaceuticals, agrochemicals, bulk and fine chemicals. N-dealkylation of amines is also an important in vivo metabolic pathway in the metabolism of xenobiotics. Identification and synthesis of drug metabolites such as N-dealkylated metabolites are necessary throughout all phases of drug development studies. In this review, different approaches for the N-dealkylation of amines including chemical, catalytic, electrochemical, photochemical and enzymatic methods will be discussed.
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