Journal
MOLECULES
Volume 27, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules27092881
Keywords
heartburn; dyspepsia; nausea; constipation; diarrhoea; phytotherapy; HMPC; mechanism of action
Funding
- Erasmus+ Programme of the European Union [2020-1-CZ01-KA203-078218]
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This article summarizes the basic pharmacological knowledge of synthetic drugs used in functional gastrointestinal disorders (FGIDs) and correlates them with the constituents of herbal medicines. The research aims to support the rational basis of empirical folk medicine and official herbal remedies in modern pharmacology.
The worldwide prevalence of gastrointestinal diseases is about 40%, with standard pharmacotherapy being long-lasting and economically challenging. Of the dozens of diseases listed by the Rome IV Foundation criteria, for five of them (heartburn, dyspepsia, nausea and vomiting disorder, constipation, and diarrhoea), treatment with herbals is an official alternative, legislatively supported by the European Medicines Agency (EMA). However, for most plants, the Directive does not require a description of the mechanisms of action, which should be related to the therapeutic effect of the European plant in question. This review article, therefore, summarizes the basic pharmacological knowledge of synthetic drugs used in selected functional gastrointestinal disorders (FGIDs) and correlates them with the constituents of medicinal plants. Therefore, the information presented here is intended as a starting point to support the claim that both empirical folk medicine and current and decades-old treatments with official herbal remedies have a rational basis in modern pharmacology.
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