4.6 Article

Green and Effective Preparation of α-Hydroxyphosphonates by Ecocatalysis

Journal

MOLECULES
Volume 27, Issue 10, Pages -

Publisher

MDPI
DOI: 10.3390/molecules27103075

Keywords

hydroxyphosphonates; hydrophosphonylation; biomass; green chemistry; aldehydes

Funding

  1. Ministry of Education and Science to the Wroclaw University of Science and Technology
  2. French funds through the EXTRA-Zn project (ADEME-Agence de la transition ecologique) [1972C0007, 1972C0025, 2019-2022]

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A green and effective approach for the synthesis of structurally diversed alpha-hydroxyphosphonates via hydrophosphonylation of aldehydes under solventless conditions and promoted by biosourced catalysts Eco-MgZnOx is presented. The ecocatalysts were prepared from Zn-hyperaccumulating plant species Arabidopsis halleri, with simple and benign thermal treatment of leaves rich in Zn, and without any further chemical treatment. The study demonstrates the potential use of the ecocatalysts in hydrophosphonylation of aldehydes, leading to various alpha-hydroxyphosphonate derivatives, which are critical building blocks in the modern chemical industry.
A green and effective approach for the synthesis of structurally diversed alpha-hydroxyphosphonates via hydrophosphonylation of aldehydes under solventless conditions and promoted by biosourced catalysts, called ecocatalysts Eco-MgZnOx is presented. Ecocatalysts were prepared from Zn-hyperaccumulating plant species Arabidopsis halleri, with simple and benign thermal treatment of leaves rich in Zn, and without any further chemical treatment. The elemental composition and structure of Eco-MgZnOx were characterized by MP-AES, XRPD, HRTEM, and STEM-EDX techniques. These analyses revealed a natural richness in two unusual and valuable mixed zinc-magnesium and iron-magnesium oxides. The ecocatalysts were employed in this study to demonstrate their potential use in hydrophosphonylation of aldehydes, leading to various alpha-hydroxyphosphonate derivatives, which are critical building blocks in the modern chemical industry. Computational chemistry was performed to help discriminate the role of some of the constituents of the mixed oxide ecocatalysts. High conversions, broad substrate scope, mild reaction conditions, and easy purification of the final products together with simplicity of the preparation of the ecocatalysts are the major advantages of the presented protocol. Additionally, Eco-MgZnOx-P could be recovered and reused for up to five times.

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