Journal
MOLECULES
Volume 27, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules27092652
Keywords
Philadelphus coronarius; chemical compounds; penetration enhancers; cytotoxicity; ointments; topical application; antimicrobial; anti-inflammatory; antioxidant
Funding
- National Research, Development and Innovation Fund of Hungary [TKP2021-EGA-18]
- project Debrecen Venture Table S Catapult [EFOP-3.6.1-16-2016-0002]
- European Union
- European Social Fund
- Ministry of Hungary Domus Hungarica
- Richter Gedeon Talent Foundation
- [GINOP-2.3.4-15-2020-00008]
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The study aimed to explore the medicinal value of Philadelphus coronarius and develop topical ointments. The composition and excipients of the ointments were found to greatly impact drug release, texture, and bioavailability. Despite being effective against Escherichia coli and Staphylococcus aureus, the P. coronarius leaf did not significantly decrease IL-4 production in HaCaT cells. The topical application of P. coronarius could be a valuable addition to antimicrobial therapy.
Philadelphus coronarius is a versatile plant and its use in folk medicine has a long tradition; however, scientifically, the medical utilization of the herb is a less explored research field. The aim of our study was to identify and determine the quantity of the bioactive compounds of both the leaf and the flower and prepare a lyophilized product of them, from which medical ointments were formulated, since the topical application of P. coronarius has also not been studied. In vitro drug release, texture analysis and biocompatibility experiments were carried out, as well as the investigation of microbiological, antioxidant and anti-inflammatory properties. According to our results the composition and the selected excipients of the ointments have a great impact on the drug release, texture and bioavailability of the preparation. During the microbiological testing, the P. coronarius leaf was effective against Escherichia coli and Staphylococcus aureus, but it did not significantly decrease IL-4 production when it was tested on HaCaT cells. P. coronarius is a promising herb, and its topical application in antimicrobial therapy can be a useful addition to modern medical therapy.
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