Journal
MOLECULES
Volume 27, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/molecules27092645
Keywords
nitroindoline cages; calcium chelators; chemical synthesis; photolysis; photostability
Funding
- NIH [HL19242-27]
- Francis Crick Institute - Cancer Research UK [FC001029, FC001066, FC001999]
- UK Medical Research Council [FC001029, FC001066, FC001999]
- Wellcome Trust [FC001029, FC001066, FC001999]
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Neuroactive amino acids derivatised with a photolabile nitroindolinyl group at their carboxylate groups are effective for sub-micromolar release of neuroactive amino acids in physiological solutions. However, this does not apply to calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, while nitroindolinyl-caged EDTA photolyses only in the presence of saturated calcium ions.
Neuroactive amino acids derivatised at their carboxylate groups with a photolabile nitroindolinyl group are highly effective reagents for the sub-mu s release of neuroactive amino acids in physiological solutions. However, the same does not apply in the case of calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, whereas nitroindolinyl-caged EDTA photolyses only when saturated with calcium ions.
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