Journal
MOLECULES
Volume 27, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/molecules27072233
Keywords
natural products; one-pot reactions; alkaloids; Masuda borylation-Suzuki coupling
Funding
- Deutsche Forschungsgemeinschaft [GRK 2158]
- Fonds der Chemischen Industrie
Ask authors/readers for more resources
In this study, a new synthetic method was developed for the concise synthesis of various marine indole alkaloids. The method demonstrated high yields and simplicity.
N-Protected 3-iodoindoles were reacted with (di)azine halides in a sequentially Pd-catalyzed one-pot fashion, i.e., by Masuda borylation-Suzuki coupling (MBSC) sequence. This methodology was successfully applied to the concise syntheses of marine indole alkaloids meridianin C, D, F, and G, as well as to the bisindole alkaloid scalaridine A, which were obtained in moderate to excellent yield.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available