Journal
MOLECULES
Volume 27, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/molecules27103062
Keywords
radiopharmaceuticals; theranostics; radionuclide; chelator; pharmacokinetic-modifying linker
Funding
- Directorate of Research and Community Services Universitas Padjadjaran
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Research on therapeutic radiopharmaceuticals has been increasing in importance, with radiometal-based drugs gaining significant attention. Researchers can use the characteristics of various commonly used chemical components provided in this paper as a guide.
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as a result of the growing research interest in personalized medicine to improve diagnostic accuracy and intensify intensive therapy while limiting side effects. Radiometal-based drugs are of substantial interest because of their greater versatility for clinical translation compared to non-metal radionuclides. This paper comprehensively discusses various components commonly used as chemical scaffolds to build radiopharmaceutical agents, i.e., radionuclides, pharmacokinetic-modifying linkers, and chelators, whose characteristics are explained and can be used as a guide for the researcher.
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