Journal
MOLECULES
Volume 27, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/molecules27051751
Keywords
microwave; green chemistry; benzimidazoles; solvent free conditions; Er(OTf)(3)
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The benzimidazole ring is a widely studied and common structure in heterocyclic pharmacophores. In this study, a simple microwave-assisted method for synthesizing 1,2-disubstituted benzimidazoles was reported. The method offers a fast and highly selective way to obtain benzimidazoles under solvent-free conditions.
The benzimidazole ring of the heterocyclic pharmacophores is one of the most widespread and studied systems in nature. The benzimidazole derivative synthesis study is a crucial point for the development of a clinically available benzimidazole-based drug. Here, we report a simple microwave assisted method for the synthesis of 1,2-disubstituted benzimidazoles. The combination of the molar ratio of N-phenyl-o-phenylenediamine:benzaldehyde (1:1) using microwave irradiation and only 1% mol of Er(OTf)(3) provides an efficient and environmental mild access to a diversity of benzimidazoles under solvent-free conditions. The proposed method allows for the obtainment of the desired products in a short time and with very high selectivity.
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