Journal
MOLECULAR PHARMACEUTICS
Volume 19, Issue 5, Pages 1410-1421Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.1c00942
Keywords
scutellarin; PLGA nanoparticles; stroke; cerebral ischemia; traditional Chinese medicine (TCM)
Funding
- National Natural Science Foundation of China [81860323]
- China Scholarship Council [201808525113]
- Natural Science Foundation of Guizhou Province [1Y401]
- Science and Technology Foundation of Guizhou Provincial Health Commission [gzwjkj 2019-1-187]
- High-level Talents Innovation and Entrepreneurship Merit-based Funding Projects of Guizhou Province [(2021)03]
- Queen's University Belfast, UK
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This study investigates the protective effect of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with scutellarin (SCU) in reducing cerebral ischemia/reperfusion (I/R) injury. The results show that SCU-PLGA NPs can increase SCU levels in the ischemic brain, reduce cerebral infarct volume, reverse histopathological changes, and attenuate cell apoptosis in the brain tissue.
This study investigates the protective effect of poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded withscutellarin (SCU), aflavone isolated from the traditional Chinese medicineErigeron breviscapus(Vant.) Hand.-Mazz., in reducingcerebral ischemia/reperfusion (I/R) injuryin vivo. The focal cerebral I/R injury model was established by occluding the middlecerebral artery for 1 h in male Sprague-Dawley (SD) rats. Our SCU-PLGA NPs exhibited an extendedin vitrorelease profile andprolonged blood circulation in rats with cerebral ischemia. More importantly, when administered intravenously once a day for 3days, SCU-PLGA NPs increased the SCU level in the ischemic brain, compared to free SCU, resulting in a significant reduction ofthe cerebral infarct volume after cerebral I/R. Furthermore, SCU-PLGA NPs reversed the histopathological changes caused bycerebral I/R injury, as well as attenuated cell apoptosis in the brain tissue, as confirmed by hematoxylin and eosin, and TUNELstaining. Ourfindings have revealed that our injectable SCU-PLGA NPs provide promising protective effects against cerebral I/Rinjury, which could be used in combination with the existing conventional thrombolytic therapies to improve stroke management
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