4.7 Article

Diet Supplementation with NUTRIOSE, a Resistant Dextrin, Increases the Abundance of Parabacteroides distasonis in the Human Gut

Journal

MOLECULAR NUTRITION & FOOD RESEARCH
Volume 66, Issue 11, Pages -

Publisher

WILEY
DOI: 10.1002/mnfr.202101091

Keywords

gut microbiota; resistant dextrin; Parabacteroides distasonis; shotgun metagenomics; soluble fiber

Funding

  1. Roquette, France

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Dietary supplementation with soluble fiber such as NUTRIOSE can modulate the gut microbiota and this study confirms its impact on the gut microbiota of healthy individuals.
Scope An imbalance of the gut microbiota (dysbiosis) is associated with numerous chronic diseases, and its modulation is a promising novel therapeutic approach. Dietary supplementation with soluble fiber is one of several proposed modulation strategies. This study aims at confirming the impact of the resistant dextrin NUTRIOSE (RD), a soluble fiber with demonstrated beneficial health effects, on the gut microbiota of healthy individuals. Methods and results Fifty healthy women are enrolled and supplemented daily with either RD (n = 24) or a control product (n = 26) during 6 weeks. Characterization of the fecal metagenome with shotgun sequencing reveals that RD intake dramatically increases the abundance of the commensal bacterium Parabacteroides distasonis. Furthermore, presence in metagenomes of accessory genes from P. distasonis, coding for susCD (a starch-binding membrane protein complex) is associated with a greater increase of the species. This suggests that response to RD might be strain-dependent. Conclusion Supplementation with RD can be used to specifically increase P. distasonis in gut microbiota of healthy women. The magnitude of the response may be associated with fiber-metabolizing capabilities of strains carried by subjects. Further research will seek to confirm that P. distasonis directly modulates the clinical effects observed in other studies.

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