Related references
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Article
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Summary: SARS-CoV-2 infection can lead to neuroinflammation and neurological symptoms, with the structural protein S1 potentially inducing these processes independently of viral infection. Experimental findings show that S1 causes various physiological and behavioral changes in rats and microglial cells in vitro, as well as alterations in neuroimmune gene and protein expression, suggesting a role in neuroinflammatory processes via receptor engagement.
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Summary: The COVID-19 pandemic is associated with significant morbidity and mortality. Experimental studies in animals infected with SARS-CoV-2 have revealed severe lung and brain damage, as well as early onset anosmia in mice. Excitingly, infusion of convalescent plasma from recovered patients has shown to protect against lethal disease, though it does not prevent anosmia.
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JOURNAL OF PATHOLOGY
(2015)
