4.5 Article

Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke

Related references

Note: Only part of the references are listed.
Article Neurosciences

O-GlcNAc Transferase (OGT) Protects Cerebral Neurons from Death During Ischemia/Reperfusion (I/R) Injury by Modulating Drp1 in Mice

Jingru Zhao et al.

Summary: Our study revealed that OGT protects against cerebral I/R injury by inhibiting the function of Drp1 in mice, suggesting that OGT may be a potential therapeutic target for cerebral I/R injury.

NEUROMOLECULAR MEDICINE (2022)

Review Neurosciences

Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies

Surojit Paul et al.

Summary: Stroke is a major cause of disability and death globally, with an increasing incidence particularly in younger age groups and low to middle-income countries. While treatment options are limited, advancements in recanalization therapy have shown promise in helping patients recover from ischemic stroke. Development of neuroprotective agents for acute ischemic stroke is urgently needed to protect the brain, extend the therapeutic time window, and improve outcomes.

EXPERIMENTAL NEUROLOGY (2021)

Article Biochemistry & Molecular Biology

ApoE4 (Δ272-299) induces mitochondrial-associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron

Tao Liang et al.

Summary: Neuronal expression of apoE4 (Delta 272-299) induces mitochondrial impairment through ER stress and MAM formation, as well as promoting GRP75 expression and mitochondrial calcium overload. These effects can be significantly mitigated by treatment with ER stress inhibitor, GRP75 inhibitor, or GRP75 silencing.

CELL AND BIOSCIENCE (2021)

Article Chemistry, Multidisciplinary

Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke

Cheng-Long Gao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Review Cell Biology

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Xin-Tong Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Article Biochemistry & Molecular Biology

Hypoxia Induces Astrocyte-Derived Lipocalin-2 in Ischemic Stroke

Fatemeh Ranjbar Taklimie et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

Ishraq Alim et al.

Article Biochemistry & Molecular Biology

Mortalin (GRP75/HSPA9) Promotes Survival and Proliferation of Thyroid Carcinoma Cells

Dmytro Starenki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Physiology

Mitofusins: Disease Gatekeepers and Hubs in Mitochondrial Quality Control by E3 Ligases

Mafalda Escobar-Henriques et al.

FRONTIERS IN PHYSIOLOGY (2019)

Article Biochemistry & Molecular Biology

Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke

Nandan K. Mondal et al.

NEUROCHEMISTRY INTERNATIONAL (2019)

Article Medicine, Research & Experimental

Vitexin reverses the autophagy dysfunction to attenuate MCAO-induced cerebral ischemic stroke via mTOR/Ulk1 pathway

Jin Jiang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Physiology

Mito-Tempo prevents nicotine-induced exacerbation of ischemic brain damage

Chun Li et al.

JOURNAL OF APPLIED PHYSIOLOGY (2018)

Review Biochemistry & Molecular Biology

Mitochondrial Dynamics in Stem Cells and Differentiation

Bong Jong Seo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Urology & Nephrology

The hallmarks of mitochondrial dysfunction in chronic kidney disease

Daniel L. Galvan et al.

KIDNEY INTERNATIONAL (2017)

Article Biochemistry & Molecular Biology

Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis

Yongping Zhang et al.

MOLECULAR CELL (2016)

Article Biochemistry & Molecular Biology

GRP75 Involves in Retinal Ganglion Cell Apoptosis After Rat Optic Nerve Crush

Gaoming Zhang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2015)

Article Biochemical Research Methods

Critical differences between two classical surgical approaches for middle cerebral artery occlusion-induced stroke in mice

Helen K. Smith et al.

JOURNAL OF NEUROSCIENCE METHODS (2015)

Article Chemistry, Medicinal

Analogues of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, As Anti-Cancer Agents

Xiaokai Li et al.

ACS MEDICINAL CHEMISTRY LETTERS (2013)

Article Biochemistry & Molecular Biology

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

Aikaterini Rousaki et al.

JOURNAL OF MOLECULAR BIOLOGY (2011)

Article Veterinary Sciences

Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging

Elizabeth Head et al.

VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE (2008)

Review Cell Biology

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

PS Brookes et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)