Journal
MOLECULAR IMMUNOLOGY
Volume 144, Issue -, Pages 117-126Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2022.02.005
Keywords
Id3; CD8 exhaustion; PD-1 blockade; Liver cancer
Categories
Funding
- Young and Middle-aged Academic and Technical Leaders in Yunnan Province/Reserve Talent Training Program [202005AC160017]
- National Natural Science Foundation of China [81960514]
- Project of Kunming Medical [2019FE001-010]
- Yunnan Health Training Project of High Level Talents [L-2019016]
- Yunnan High-level Talent Cultivation Support Plan-Famous Doctor Special [KH-SWR-MY-2020-001]
- Open Project of Gastroenterology Clinical Medicine Center [2021LCZXXF-XH02]
- Yunnan Fundamental Research Projects [2022YunJin]
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Id3 plays a protective role in CD8 T cells in liver cancer.
Id3, an inhibitor of DNA binding protein, plays important roles in the function and homeostasis of effector and memory T cells. Recent evidence has shown that Id3 is also implicated in CD8 T cell exhaustion. However, whether and how Id3 might regulate effector function or exhaustion of CD8 T cells, especially in the tumor setting, is still unknown. Here, we first showed that Id3 expression was impaired in tumor-infiltrating CD8 T cells as liver cancer progressed, especially in PD-1+Tim-3 + exhausted CD8 T cells. Enforced expression of Id3 in CD8 T cells resulted in repressed development of anti-tumor CTLs exhaustion, which offered better tumor control. And partially depletion of Id3 in CD8 T cells promoted the development of exhausted CD8 T cells. Furthermore, Id3hi CD8 T cells could respond to PD-1 blockade. Collectively, Id3 exerts protective functions in CD8 T cells for liver cancer.
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