Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mito-chondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.

Automated summary

Tsvetkov et al. (2022) identified a novel form of cell death caused by targeted accumulation of Cu in mitochondria, which leads to aggregation of lipoylated TCA cycle enzymes through direct Cu binding.