4.8 Article

H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1

Dheva Setiaputra et al.

Summary: The chromatin-binding protein 53BP1 promotes DNA repair by recruiting downstream effectors such as PTIP, RIF1, and shieldin to DNA double-strand break sites. This study reveals that RIF1 is a phosphopeptide-binding protein that directly interacts with three phosphorylated epitopes on 53BP1. The recruitment of RIF1 and an alternative mode of shieldin to DNA-damage sites, which is dependent on RIF1 but does not require its interaction with 53BP1, are both essential for efficient DNA repair.

MOLECULAR CELL (2022)

Article Biochemistry & Molecular Biology

Characterization of SETD1A haploinsufficiency in humans and Drosophila defines a novel neurodevelopmental syndrome

Joost Kummeling et al.

Summary: Mutations in histone methyltransferases (HMTs), such as SETD1A, are major contributing factors in neurodevelopmental disorders (NDDs). Identifying clinical features of the Mendelian syndrome associated with haploinsufficiency of SETD1A, this study found that individuals with SETD1A variants present with global developmental delay, intellectual disability, facial dysmorphisms, behavioral and psychiatric problems. Patient-derived cell lines with SETD1A variants showed DNA damage repair defects, suggesting these variants act as loss-of-function alleles. The study also revealed the importance of SETD1A in postmitotic neurons for normal memory function in Drosophila melanogaster, indicating a role in post development neuronal processes and cognitive functioning.

MOLECULAR PSYCHIATRY (2021)

Review Cell Biology

Control of the chromatin response to DNA damage: Histone proteins pull the strings

Juliette Ferrand et al.

Summary: DNA damage leads to changes in histone protein dynamics and modifications, impacting the stability of the epigenome. However, these alterations also play a crucial role in facilitating an efficient response to DNA damage.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD

Graeme Hewitt et al.

Summary: The loss of ALC1 increases sensitivity to PARP inhibitors, indicating the importance of nucleosome remodeling in DNA repair. ALC1 deficiency is synthetically lethal with homologous recombination deficiency, due to chromosome instability caused by unrepaired DNA gaps.

MOLECULAR CELL (2021)

Article Multidisciplinary Sciences

TRF2-independent chromosome end protection during pluripotency

Phil Ruis et al.

Summary: This study demonstrates that in mouse pluripotent embryonic stem cells and epiblast stem cells, TRF2 is largely dispensable for telomere protection, with cells exhibiting an attenuated telomeric DNA damage response and the ability to propagate for multiple generations even in the absence of TRF2. Cells exiting pluripotency rapidly switch to TRF2-dependent end protection, and embryos lacking Trf2 arrest before implantation with evidence of DNA damage response signaling and apoptosis in the non-pluripotent compartment. The formation of T-loops independently of TRF2 in ES cells explains why TRF2 is not essential for end protection during pluripotency.

NATURE (2021)

Article Cell Biology

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

Shin-Ya Isobe et al.

Summary: The study reveals that RIF1 inhibits CtIP accumulation and limits resection by the MRN complex through its effector PP1, which acts distinct from Shieldin, to prevent precocious homologous recombination in the early phase of the damage response.

CELL REPORTS (2021)

Article Biochemistry & Molecular Biology

53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Elsa Callen et al.

MOLECULAR CELL (2020)

Review Biochemistry & Molecular Biology

The role of SETD1A and SETD1B in development and disease

Andrea Kranz et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2020)

Article Cell Biology

H4K20meO recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids

Kyosuke Nakamura et al.

NATURE CELL BIOLOGY (2019)

Article Multidisciplinary Sciences

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Chirantani Mukherjee et al.

NATURE COMMUNICATIONS (2019)

Article Neurosciences

De Novo and Inherited SETD1A Variants in Early-onset Epilepsy

Xiuya Yu et al.

NEUROSCIENCE BULLETIN (2019)

Article Biochemistry & Molecular Biology

A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response

Takayuki Hoshii et al.

Article Biochemistry & Molecular Biology

Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2

Martin R. Higgs et al.

MOLECULAR CELL (2018)

Article Biochemistry & Molecular Biology

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

Enis Afgan et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Multidisciplinary Sciences

53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ

Hind Ghezraoui et al.

NATURE (2018)

Article Multidisciplinary Sciences

The shieldin complex mediates 53BP1-dependent DNA repair

Sylvie M. Noordermeer et al.

NATURE (2018)

Article Multidisciplinary Sciences

MCM2 promotes symmetric inheritance of modified histones during DNA replication

Nataliya Petryk et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks

Sihao Zheng et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Multidisciplinary Sciences

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

Winston X. Yan et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program

Rossana Foti et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Replication fork stability confers chemoresistance in BRCA-deficient cells

Arnab Ray Chaudhuri et al.

NATURE (2016)

Article Multidisciplinary Sciences

The structural basis of modified nucleosome recognition by 53BP1

Marcus D. Wilson et al.

NATURE (2016)

Article Biochemical Research Methods

The Perseus computational platform for comprehensive analysis of (prote)omics data

Stefka Tyanova et al.

NATURE METHODS (2016)

Article Biochemistry & Molecular Biology

BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks

Martin R. Higgs et al.

MOLECULAR CELL (2015)

Article Multidisciplinary Sciences

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

Guotai Xu et al.

NATURE (2015)

Article Multidisciplinary Sciences

Histone demethylase KDM5B is a key regulator of genome stability

Xin Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

The histone demethylase LSD1/KDM1A promotes the DNA damage response

Nima Mosammaparast et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

Cristina Escribano-Diaz et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark

Amelie Fradet-Turcotte et al.

NATURE (2013)

Article Biochemistry & Molecular Biology

Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination

Jiangbo Tang et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)

Article Multidisciplinary Sciences

53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

Michal Zimmermann et al.

SCIENCE (2013)

Article Multidisciplinary Sciences

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

Michela Di Virgilio et al.

SCIENCE (2013)

Article Biochemistry & Molecular Biology

Regulation of Homologous Recombination by RNF20-Dependent H2B Ubiquitination

Kyosuke Nakamura et al.

MOLECULAR CELL (2011)

Article Biochemistry & Molecular Biology

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation

Weijun Feng et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Multidisciplinary Sciences

PTIP Promotes Chromatin Changes Critical for Immunoglobulin Class Switch Recombination

Jeremy A. Daniel et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

Simone Difilippantonio et al.

NATURE (2008)

Article Multidisciplinary Sciences

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Shuhei Matsuoka et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

The retinoblastoma binding protein RBP2 is an H3K4 demethylase

Robert J. Klose et al.