4.7 Review

Targeting the RNA m6A modification for cancer immunotherapy

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Off-the-Shelf Prostate Stem Cell Antigen-Directed Chimeric Antigen Receptor Natural Killer Cell Therapy to Treat Pancreatic Cancer

Kun-Yu Teng et al.

Summary: This study demonstrates the effectiveness of PSCA CAR_s15 NK cells in suppressing pancreatic cancer both in vitro and in vivo, without causing systematic toxicity. These findings provide a strong rationale for further clinical development.

GASTROENTEROLOGY (2022)

Article Biology

m6A modifications regulate intestinal immunity and rotavirus infection

Anmin Wang et al.

Summary: The study found that m6A modification plays an antiviral role in the intestinal immune defense against rotavirus infection. Rotavirus infection induces global m6A modifications, and mice lacking the m6A writer enzyme METTL3 show resistance to rotavirus infection. During rotavirus infection, IRF7 is identified as a primary m6A target, and loss of METTL3 enhances Irf7 mRNA stability and IFN expression. Deficiency in IRF7 attenuates IFN expression and restores susceptibility to rotavirus infection.

ELIFE (2022)

Article Biotechnology & Applied Microbiology

Expression pattern of m6A regulators is significantly correlated with malignancy and antitumor immune response of breast cancer

Xiaofang He et al.

Summary: This study revealed that the expression pattern of m(6)A regulators in breast cancer is significantly correlated with RNA methylation modification, overall survival, PI3K/AKT and KRAS signaling, angiogenesis, and antitumor immune response. These findings suggest that m(6)A regulators could serve as potential targets and biomarkers for immunotherapy in breast cancer.

CANCER GENE THERAPY (2021)

Article Cell Biology

m6A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer

Lei Xue et al.

Summary: In NSCLC, lncRNA ABHD11-AS1 is upregulated and promotes proliferation and the Warburg effect. METTL3 enhances ABHD11-AS1 transcript stability to increase its expression.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Review Medicine, Research & Experimental

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Sreya Bagchi et al.

Summary: This article highlights the significance of immune checkpoint inhibitors in cancer immunotherapy and the research findings on the changes in local and systemic immune cells after treatment. It emphasizes the need for understanding the requirements for an effective and safe antitumor immune response following ICI therapy.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021 (2021)

Review Biochemistry & Molecular Biology

The RNA m6A writer METTL14 in cancers: Roles, structures, and applications

Huimin Zhou et al.

Summary: m(6)A modification is the most abundant and diverse epigenetic modification of mRNAs in eukaryotes, regulating biological metabolism, cell differentiation, and responses to diseases. METTL3 and METTL14 are key components of the m(6)A writer complex, with METTL14 crucial for complex integrity and recognizing special RNA substrates, and its roles in cancer are currently being extensively reviewed.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Article Genetics & Heredity

Polymorphisms in METTL3 gene and hepatoblastoma risk in Chinese children: A seven-center case-control study

Huitong Chen et al.

Summary: The study revealed an association between METTL3 gene polymorphisms and hepatoblastoma risk. While no significant correlation was found in single genotype analysis, individuals with 2-4 risk genotypes had an increased risk of hepatoblastoma in the combined analysis. Carriers of 2-4 risk genotypes were particularly susceptible among subjects aged under 17 months and females.
Article Oncology

N6-methyladenosine (m6A)-mediated messenger RNA signatures and the tumor immune microenvironment can predict the prognosis of hepatocellular carcinoma

Shen Shen et al.

Summary: This study identified three different m6A modification subtypes in hepatocellular carcinoma (HCC) patients, which were associated with different immune cell infiltration phenotypes in the tumor immune microenvironment (TIME). Low expression of METTL3 was correlated with increased infiltration of dendritic cells (DCs) in the TIME, and patients with low m6A scores had better overall survival and 5-year survival rates.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

Article Cell Biology

The m6A methylome of SARS-CoV-2 in host cells

Jun'e Liu et al.

Summary: The study found that SARS-CoV-2 genomic RNA is dynamically N-6-methyladenosine (m(6)A)-modified in human and monkey cells, and the m(6)A methylation negatively regulates SARS-CoV-2 infection. SARS-CoV-2 infection triggers a global increase in host m(6)A methylome.

CELL RESEARCH (2021)

Article Multidisciplinary Sciences

METTL3-dependent m6A modification programs T follicular helper cell differentiation

Yingpeng Yao et al.

Summary: This study demonstrates the importance of RNA methylation in T-FH effector differentiation and subsequent antibody formation by stabilizing Tcf7 transcripts.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

Huilong Yin et al.

Summary: The study reveals that deletion of Mettl3 in myeloid cells promotes tumor growth and metastasis, as well as affecting the efficacy of PD-1 checkpoint blockade therapy.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

m6A Regulators Is Differently Expressed and Correlated With Immune Response of Esophageal Cancer

Huaying Zhao et al.

Summary: This study revealed that aberrations in m6A regulators are closely associated with prognosis in esophageal cancer, with some regulators significantly correlated to disease severity and poor outcomes. The levels of m6A regulators are also related to the expression of immune regulators and immune infiltration levels in EC, suggesting their involvement in tumor progression through RNA binding and cell proliferation regulation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

The role of N6-methyladenosine mRNA in the tumor microenvironment

Min Li et al.

Summary: The widely studied N6-methyladenosine (m6A) modification of mRNA has shown conflicting effects on tumor progression. In addition to its impact on tumor cells, m6A mRNA also plays a crucial role in stromal cells within the tumor microenvironment.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

Article Oncology

An Oncolytic Virus Expressing IL15/IL15Rα Combined with Off-the-Shelf EGFR-CAR NK Cells Targets Glioblastoma

Rui Ma et al.

Summary: The study demonstrated that the combination therapy of an oncolytic virus expressing the IL15/IL15Rα complex and off-the-shelf EGFR-CAR NK cells elicited strong antitumor responses in glioblastoma. This therapy significantly inhibited tumor growth and improved survival rates, offering a promising strategy for the clinical management of this devastating disease.

CANCER RESEARCH (2021)

Article Cell Biology

Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance

Yi Liu et al.

Summary: Research has identified the m(6)A demethylase FTO as a key regulator in tumors, impacting immune surveillance through glycolytic metabolism regulation. Knockdown of FTO impairs tumor cell glycolytic activity, restores CD8(+) T cell function, and inhibits tumor growth. Additionally, the development of the small-molecule compound Dac51 can block FTO-mediated immune evasion and synergize with checkpoint blockade for improved tumor control.

CELL METABOLISM (2021)

Article Immunology

m6A Regulator-Mediated Methylation Modification Patterns and Characteristics of Immunity in Blood Leukocytes of COVID-19 Patients

Xiangmin Qiu et al.

Summary: The study revealed a significantly higher m(6)A modification level in blood leukocytes of COVID-19 patients compared to non-COVID-19 patients, which was associated with CD4(+) T cells. A protective model based on nine selected genes showed excellent predictive value in COVID-19 outcomes, with the protective score being correlated with specific indicators.

FRONTIERS IN IMMUNOLOGY (2021)

Review Biotechnology & Applied Microbiology

The evolving landscape of N6-methyladenosine modification in the tumor microenvironment

Yunru Gu et al.

Summary: The tumor microenvironment is a heavily researched topic, with RNA methylation playing a pivotal role in shaping it. The m(6)A modification influences biological processes of cancer cells and stromal cells through regulation of transcription and protein expression, characterizing the TME.

MOLECULAR THERAPY (2021)

Article Multidisciplinary Sciences

Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia

Eliza Yankova et al.

Summary: The study identified a highly potent and selective catalytic inhibitor of METTL3, STM2457, which shows potential therapeutic value in treating AML. Treatment with this inhibitor leads to reduced AML growth, increased differentiation and apoptosis, and decreased m(6)A levels on leukemogenic mRNAs. In vivo pharmacological inhibition of METTL3 results in impaired engraftment and prolonged survival in mouse models of AML.

NATURE (2021)

Article Multidisciplinary Sciences

Pooled CRISPR screening identifies m6A as a positive regulator of macrophage activation

Jiyu Tong et al.

Summary: Research has identified the important role of METTL3-mediated m(6)A modification in host immune responses, regulating macrophage activation through the TLR signaling pathway. This may serve as a potential target for cancer immunotherapy.

SCIENCE ADVANCES (2021)

Article Oncology

YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy

Jian Hu et al.

Summary: YTHDF1 is implicated in human cancers with potential as a prognostic and immunological biomarker across cancer types. It plays a crucial role in the tumor microenvironment, immune regulation, and has associations with prognosis, immune checkpoints, and tumor mutational burden. YTHDF1 may serve as a novel target for tumor immunotherapy.

FRONTIERS IN ONCOLOGY (2021)

Review Cell Biology

The Role of RNA Methyltransferase METTL3 in Hepatocellular Carcinoma: Results and Perspectives

Fan Pan et al.

Summary: Hepatocellular carcinoma (HCC) is the 6th most prevalent cancer globally, and m6A modification may play a role in its pathogenesis. METTL3, a key methyltransferase, is involved in the carcinogenesis and progression of HCC.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Chemistry, Multidisciplinary

Rational Design of Novel Anticancer Small-Molecule RNA m6A Demethylase ALKBH5 Inhibitors

Simona Selberg et al.

Summary: Two new ALKBH5 inhibitors were found to significantly suppress the proliferation of leukemia cell lines, with IC50 values ranging from 1.38 to 16.5 μM. However, the effect on another leukemia cell line and glioblastoma cell line was minimal. This demonstrates the potential of ALKBH5 inhibition as a selective antiproliferative strategy for certain cancer cell types.

ACS OMEGA (2021)

Article Oncology

The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

Lihui Dong et al.

Summary: The study reveals that the m(6)A methyltransferase Mettl14 in TAMs plays a role in modulating the function of CD8(+) T cells by regulating C1q(+) TAMs, ultimately affecting tumor progression.

CANCER CELL (2021)

Article Oncology

M(6)A Demethylase ALKBH5 Regulates PD-L1 Expression and Tumor Immunoenvironment in Intrahepatic Cholangiocarcinoma

Xinyao Qiu et al.

Summary: This study identifies PD-L1 mRNA as a target of ALKBH5 and reveals a role for ALKBH5 in regulating the tumor immune microenvironment and immunotherapy efficacy. These findings suggest a new regulatory mechanism for PD-L1 involving mRNA epigenetic modification by ALKBH5, as well as a potential role for ALKBH5 in cancer immunotherapies.

CANCER RESEARCH (2021)

Article Cell Biology

The role of YTH domain containing 2 in epigenetic modification and immune infiltration of pan-cancer

Chiyuan Zhang et al.

Summary: YTHDC2 plays a significant role in cancer, with different mutations and methylation levels affecting patient prognosis; its main molecular mechanisms include catalytic activity and helicase activity. Additionally, YTHDC2 is closely associated with tumor immune infiltration and has high diagnostic value in seven types of cancer.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Review Oncology

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

Wei Huang et al.

Summary: This review summarizes the role of N6-methyladenosine in the transcriptome and discusses the function of m6A methyltransferases in regulating cancer biology. The article highlights the use of m6A methyltransferases in mediating therapy resistance and discusses the clinical potential of targeted strategies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

Jaclyn M. Einstein et al.

Summary: RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene expression regulation, and disrupting YTHDF2-dependent mRNA degradation can induce apoptosis in triple-negative breast cancer (TNBC) cells and tumors. Our study identified 57 RBP candidates with distinct functions in supporting MYC-driven oncogenic pathways, highlighting the therapeutic potential of RBPs, especially YTHDF2, in counteracting global mRNA synthesis in MYC-driven breast cancers.

MOLECULAR CELL (2021)

Article Biochemistry & Molecular Biology

Epitranscriptomic editing of the RNA N6-methyladenosine modification by dCasRx conjugated methyltransferase and demethylase

Zhen Xia et al.

Summary: A bidirectional dCasRx epitranscriptome editing platform was developed to manipulate m6A modifications on RNA transcripts, revealing the molecular function of YTHDF proteins in m6A-mediated mRNA degradation.

NUCLEIC ACIDS RESEARCH (2021)

Article Oncology

METTL3-mediated m6A modification of Bcl-2 mRNA promotes non-small cell lung cancer progression

Yongxi Zhang et al.

Summary: This study revealed that METTL3 overexpression in non-small cell lung cancer cells promoted cell viability and migration, while decreased METTL3 had the opposite effect. Furthermore, METTL3 increased Bcl-2 translation via m6A modification, affecting the survival and migration of NSCLC cells.

ONCOLOGY REPORTS (2021)

Article Microbiology

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

Xueyan Zhang et al.

Summary: Our study demonstrated that SARS-CoV-2 RNA undergoes m(6)A modification by host m(6)A machinery, altering the expression patterns of methyltransferases and demethylases. METTL3 and FTO levels were linked to viral replication, with METTL3 interacting with viral RdRp to influence both distribution and posttranslational modification. Host m(6)A components interacted with viral proteins to modulate viral replication.
Article Multidisciplinary Sciences

METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells

Hao Song et al.

Summary: The m(6)A methylation protects the homeostasis and tumor immunosurveillance function of NK cells.

NATURE COMMUNICATIONS (2021)

Article Oncology

Hijacking TYRO3 from Tumor Cells via Trogocytosis Enhances NK-cell Effector Functions and Proliferation

Ting Lu et al.

Summary: The study shows that NK cells can acquire TYRO3 from tumor cells via trogocytosis, resulting in enhanced cytotoxicity and IFNγ production. The activation status of NK cells and TYRO3 expression levels on donor cells correlate positively with trogocytosis levels.

CANCER IMMUNOLOGY RESEARCH (2021)

Article Pharmacology & Pharmacy

YTHDF2 is a Potential Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma

Ganglin Su et al.

Summary: The study revealed that YTHDF2 may serve as a potential indicator of immune infiltration in KIRC and is associated with the overall survival and disease-free survival of patients.

FRONTIERS IN PHARMACOLOGY (2021)

Article Genetics & Heredity

METTL14 Acts as a Potential Regulator of Tumor Immune and Progression in Clear Cell Renal Cell Carcinoma

Tianbo Xu et al.

Summary: The study identified the METTL14/CCL5/Tregs axis as a potential signaling pathway for regulating tumor immunity in ccRCC, and it could be novel therapeutic targets.

FRONTIERS IN GENETICS (2021)

Article Multidisciplinary Sciences

m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity

Jing Zhou et al.

Summary: The m(6)A eraser ALKBH5 plays a crucial role in controlling the pathogenicity of CD4(+) T cells during autoimmunity, as its deficiency results in weakened immune responses and reduced recruitment of neutrophils into the central nervous system.

SCIENCE ADVANCES (2021)

Article Oncology

N6-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1

Duo Wang et al.

Summary: This study comprehensively analyzed the prognostic value of all 33 m6A RNA methylation regulators in GC, identifying fat mass and obesity-associated protein (FTO) as a key prognostic factor for overall survival (OS) of GC patients. FTO was found to promote GC metastasis by upregulating the expression of Integrin beta 1(ITGB1) via decreasing its m6A level.

FRONTIERS IN ONCOLOGY (2021)

Review Cell Biology

Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation

Ming He et al.

Summary: PROTAC is a new technology for inducing protein degradation using small molecules, which shows advantages in overcoming tumor resistance, affecting non-enzymatic functions of target proteins, degrading undruggable targets, and providing rapid and reversible chemical knockout tools. However, it also faces challenges and issues as a rapidly developing new chemical biology technology.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Medicine, General & Internal

m6A RNA Methylation Regulator YTHDF1 Correlated With Immune Microenvironment Predicts Clinical Outcomes and Therapeutic Efficacy in Breast Cancer

Ying Hu et al.

Summary: The dysregulation of m(6)A regulator YTHDF1 in breast cancer is related to poor prognosis. High expression of YTHDF1 is associated with cancer-related pathways and immune cells, as well as higher tumor mutation burden.

FRONTIERS IN MEDICINE (2021)

Review Biochemistry & Molecular Biology

iPSC-Derived Natural Killer Cells for Cancer Immunotherapy

Peter Karagiannis et al.

Summary: The discovery of human pluripotent stem cells (PSCs) has led to the exploration of induced pluripotent stem cells (iPSCs) as a potential universal cell source for therapies, including cancer immunotherapies using natural killer (NK cells). iPSCs offer advantages in quality and flexibility compared to primary NK cells, and there are various protocols for genetic modification and differentiation into NK cells. However, there are challenges that need to be addressed before iPSC-based NK cell immunotherapies can become mainstream in clinical settings.

MOLECULES AND CELLS (2021)

Article Oncology

YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer

Kazuo Tsuchiya et al.

Summary: The study found that high expressions of both YTHDF1 and YTHDF2 are associated with a favorable prognostic outcome of NSCLC patients, a greater amount of TILs, and downregulation of PD-L1. These two proteins may be novel prognostic and druggable targets related to the tumor-immune microenvironment in lung cancers.

ONCOIMMUNOLOGY (2021)

Article Immunology

The RNA m6A reader YTHDF2 controls NK cell antitumor and antiviral immunity

Shoubao Ma et al.

Summary: The N-6-methyladenosine modification plays a crucial role in NK cell immunity, with YTHDF2 being a key reader; YTHDF2 maintains NK cell homeostasis and function, modulating NK cell survival and proliferation through a positive feedback loop.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Review Biochemistry & Molecular Biology

The role of m6A modification in the biological functions and diseases

Xiulin Jiang et al.

Summary: This paper highlights the importance of m6A RNA modification in eukaryotic RNA, including the roles of m6A methyltransferases, demethylases, and binding proteins. It emphasizes the crucial role of m6A RNA modification in the development of human cancers and discusses its impact on the physiological and pathological progressions of hematopoietic, central nervous, and reproductive systems.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Review Medicine, Research & Experimental

Epigenetic Regulation of m6A Modifications in Human Cancer

Wei Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Article Biochemistry & Molecular Biology

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation

Tao Liu et al.

NUCLEIC ACIDS RESEARCH (2020)

Review Genetics & Heredity

Molecular Mechanisms Driving mRNA Degradation by m(6)A Modification

Yujin Lee et al.

TRENDS IN GENETICS (2020)

Review Oncology

m6A-binding proteins: the emerging crucial performers in epigenetics

Yanchun Zhao et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Multidisciplinary Sciences

Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver

Sabrina Jabs et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein

Jiexin Li et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

RNA N6-methyladenosine demethylase FTO regulates PD-L1 expression in colon cancer cells

Nobuhiro Tsuruta et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

Christopher Wilson et al.

NATURE BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

Na Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Medicine, Research & Experimental

Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer

Huan-he Ni et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Review Oncology

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Ahmet Yilmaz et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Review Cell Biology

The role of m6A modification in physiology and disease

Chuan Yang et al.

CELL DEATH & DISEASE (2020)

Review Oncology

Role of RNA modifications in cancer

Isaia Barbieri et al.

NATURE REVIEWS CANCER (2020)

Review Immunology

Dendritic cells in cancer immunology and immunotherapy

Stefanie K. Wculek et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Oncology

The Critical Role of RNA m6A Methylation in Cancer

Qing Lan et al.

CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response

Ruiqing Yu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biotechnology & Applied Microbiology

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Piotr S. Kowalski et al.

MOLECULAR THERAPY (2019)

Review Biochemistry & Molecular Biology

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Hailing Shi et al.

MOLECULAR CELL (2019)

Article Multidisciplinary Sciences

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Huamin Wang et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

Ting Li et al.

MOLECULAR CANCER (2019)

Article Biotechnology & Applied Microbiology

m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways

Ru Deng et al.

ONCOTARGETS AND THERAPY (2019)

Article Multidisciplinary Sciences

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

Seungwon Yang et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway

Wen Peng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Article Biochemistry & Molecular Biology

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

Xiao-Min Liu et al.

NATURE CHEMICAL BIOLOGY (2019)

Review Immunology

Tissue-Resident Memory T Cells in Cancer Immunosurveillance

Simone L. Park et al.

TRENDS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression

Yulin Shi et al.

NATURE COMMUNICATIONS (2019)

Review Oncology

The clinical role of the TME in solid cancer

Nicolas A. Giraldo et al.

BRITISH JOURNAL OF CANCER (2019)

Review Chemistry, Multidisciplinary

Tailoring Nanomaterials for Targeting Tumor-Associated Macrophages

Muhammad Ovais et al.

ADVANCED MATERIALS (2019)

Review Medicine, Research & Experimental

An Overview of the CRISPR-Based Genomic- and Epigenome-Editing System: Function, Applications, and Challenges

Saeed Bozorg Qomi et al.

ADVANCED BIOMEDICAL RESEARCH (2019)

Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

Review Chemistry, Multidisciplinary

Nanomaterials for Cancer Precision Medicine

Yilong Wang et al.

ADVANCED MATERIALS (2018)

Article Biochemistry & Molecular Biology

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling

Rui Su et al.

Letter Cell Biology

m6A mRNA methylation sustains Treg suppressive functions

Jiyu Tong et al.

CELL RESEARCH (2018)

Review Biochemistry & Molecular Biology

Understanding the tumor immune microenvironment (TIME) for effective therapy

Mikhail Binnewies et al.

NATURE MEDICINE (2018)

Review Medicine, General & Internal

Chimeric Antigen Receptor Therapy

Carl H. June et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Review Immunology

The Broad Spectrum of Human Natural Killer Cell Diversity

Aharon G. Freud et al.

IMMUNITY (2017)

Review Immunology

The Mechanisms of T Cell Selection in the Thymus

Hiroyuki Takaba et al.

TRENDS IN IMMUNOLOGY (2017)

Review Genetics & Heredity

Advances in the delivery of RNA therapeutics: from concept to clinical reality

James C. Kaczmarek et al.

GENOME MEDICINE (2017)

Review Biochemistry & Molecular Biology

Dynamic RNA Modifications in Gene Expression Regulation

Ian A. Roundtree et al.

Review Oncology

Immunotherapy and tumor microenvironment

Haidong Tang et al.

CANCER LETTERS (2016)

Editorial Material Oncology

A Milestone Review on How Macrophages Affect Tumor Growth

Christophe Caux et al.

CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases

Ping Wang et al.

MOLECULAR CELL (2016)

Review Oncology

NK cells and cancer: you can teach innate cells new tricks

Maelig G. Morvan et al.

NATURE REVIEWS CANCER (2016)

Article Biochemistry & Molecular Biology

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

Claudio R. Alarcon et al.

Article Chemistry, Multidisciplinary

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Tianlu Wang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2015)

Review Genetics & Heredity

Strategies for precision modulation of gene expression by epigenome editing: an overview

Benjamin I. Laufer et al.

EPIGENETICS & CHROMATIN (2015)

Article Biochemistry & Molecular Biology

Meclofenamic acid selectively inhibits FTO demethylation of m(6)A over ALKBH5

Yue Huang et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Synthesis of a FTO Inhibitor with Anticonvulsant Activity

Guanqun Zheng et al.

ACS CHEMICAL NEUROSCIENCE (2014)

Review Immunology

Tumor-Associated Macrophages: From Mechanisms to Therapy

Roy Noy et al.

IMMUNITY (2014)

Article Biochemistry & Molecular Biology

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

Chao Xu et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

Article Chemistry, Multidisciplinary

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

Baoen Chen et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

Review Immunology

Cross-presentation by dendritic cells

Olivier P. Joffre et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Article Biotechnology & Applied Microbiology

Therapeutic siRNA silencing in inflammatory monocytes in mice

Florian Leuschner et al.

NATURE BIOTECHNOLOGY (2011)

Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

Review Multidisciplinary Sciences

Taking dendritic cells into medicine

Ralph M. Steinman et al.

NATURE (2007)

Review Immunology

T-cell development and the CD4-CD8 lineage decision

RN Germain

NATURE REVIEWS IMMUNOLOGY (2002)