Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 545, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2022.111574
Keywords
BPA; BPS; BPF; Oxidative stress; Antioxidant enzymes; Granulosa cells
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC) [401511]
- Ontario Veterinary College (OVC) Scholarship in the Department of Biomedical Sciences at the University of Guelph
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Research has found that Bisphenol A (BPA) and its analogs can induce oxidative stress within bovine granulosa cells, although not necessarily through common mechanisms. Therefore, the use of BPA analogs may need to be re-considered.
Bisphenol A is a widespread endocrine disruptor with numerous effects on reproductive functions. Limitations on BPA in manufacturing has prompted the use of analogs, such as BPS and BPF, with limited research on their safety. The objective of this study was to evaluate the effects of BPA and its analogs on oxidative stress levels within bovine granulosa cells and to measure the expression of key antioxidant genes. Results indicate that BPA and BPF reduce cell viability and induce mitochondrial dysfunction and all three bisphenols increased production of reactive oxygen species as early as 12hrs post exposure. BPA increased the levels of antioxidants at 12hrs at the mRNA and protein levels, while these results were not significant at 48hrs. These results together suggest that BPA and its analogs can induce oxidative stress within bovine granulosa cells, although not necessarily through common mechanisms. Therefore, the use of BPA analogs may have to be re-considered.
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