Journal
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 549, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2022.111616
Keywords
FXR; Bile acids; Glucose homeostasis; Lipid metabolism; Non-enterohepatic tissues
Categories
Funding
- University of Illinois at Urbana-Champaign
- Cancer center of Illinois [R01 DK130317]
- NIDDK [R01 DK113080]
Ask authors/readers for more resources
This review examines the classical and non-canonical tissue-specific roles of FXR in regulating lipids and glucose homeostasis, highlighting the significance of FXR signaling in modulating metabolic processes. It also emphasizes that tissue-specific modulation of FXR may be the key to overcoming some of the adverse clinical effects.
Farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates bile acid homeostasis along with nutrient metabolism. In addition to the gastrointestinal (GI) tract, FXR expression has been widely noted in kidney, adrenal gland, pancreas, adipose, skeletal muscle, heart, and brain. Except for the liver and gut, the relevance of FXR signaling in metabolism in other tissues remains poorly understood. This review examines the classical and non-canonical tissue-specific roles of FXR in regulating, lipids, and glucose homeostasis under normal and diseased states. FXR activation has been reported to be protective against cholestasis, nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), type 2 diabetes, cardiovascular and kidney diseases. Several ongoing clinical trials are investigating FXR ligands as a therapeutic target for primary biliary cholangitis (PBC) and NASH, which substantiate the significance of FXR signaling in modulating metabolic processes. This review highlights that FXR ligands, albeit an attractive therapeutic target for treating metabolic diseases, tissue-specific modulation of FXR may be the key to overcoming some of the adverse clinical effects.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available