Journal
MICROSCOPY RESEARCH AND TECHNIQUE
Volume 85, Issue 8, Pages 2857-2865Publisher
WILEY
DOI: 10.1002/jemt.24134
Keywords
antibacterial; characterization; composite oxides; nanoparticles; Ocimum basilicum
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Nanoparticles play a crucial role in the development of antibacterial substances, as their smaller size allows for improved antibacterial activity through bacterial cell wall lysis. In this study, various nanoparticles were synthesized using a green method from Ocimum basilicum leaves extract. The nanoparticles were characterized using established techniques and tested for their antibacterial activity, with ZnO nanoparticles showing promise against Pseudomonas aeruginosa.
Nanoparticles plays a key role in the development of novel antibacterial substances against various pathogenic microorganisms. These nanoparticles due to their smaller size could be very effective as they can improve the antibacterial activity through lysis of bacterial cell wall. In the present research work, ZnO, MgO, NiO, AlO nanoparticles, and Mg-NiO, and Al-ZnO composite oxides were synthesized by green method from Ocimum basilicum leaves extract. The nanoparticles formed were evaluated using FTIR, XRD, EDX, and SEM to confirm the formation of NPs and to determine the morphology, elemental composition, shape and size, composition, and nature of bonds present in the NPs. Further, the NPs were tested for their antibacterial activity. In particular, ZnO NPs showed a good inhibitory effect against Pseudomonas aeruginosa with 20 mm zone of inhibition. Hence, the process reported herein could be optimized for large-scale preparation of NPs. Research Highlights Green synthesis of ZnO, MgO, NiO, AlO nanoparticles, and Mg-NiO, and Al-ZnO composite oxides using Ocimum basilicum leaves extract NPs were characterized by various established characterization techniques like FTIR, XRD, EDX, and SEM. NPs showed antibacterial activity which was investigated by agar well diffusion method against Bacillus cereus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus. The method proved to be very simple, cost-efficient, and convenient.
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