Journal
MICROSCOPY AND MICROANALYSIS
Volume 28, Issue 5, Pages 1696-1702Publisher
OXFORD UNIV PRESS
DOI: 10.1017/S1431927622000733
Keywords
anticancer compound; antioxidant activity; antiproliferative activity; selective activity; toxicity
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Funding
- ANCD [20.80009.5007.10, 20.80009.7007.12]
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Five compounds were synthesized and their antiproliferative properties and antioxidant effects were tested. The compounds showed higher anticancer activity and antioxidant effects compared to Doxorubicin.
Five compounds 2-(2-hydroxybenzylidene)-N-(prop-2-en-1-yl)hydrazinecarbothioamide (H2L), bis[mu(2)-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diaquadicopper(II) nitrate (1), bis[mu(2)-2-({2-[(prop-2-en-1-yl)carbamothioyl]hydrazinylidene}methyl)phenolato-S,N,O:O]diimidazoldicopper(II) nitrate (2), bis[mu(2)-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper(II) nitrate (3), bis[mu(2)-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds toward cancer cell lines RD, HeLa, and normal cell line MDCK have been investigated. The tested complexes surpass Doxorubicin (DOXO) in the efficiency of anticancer activity as their IC50 values toward cancer cells are lower than the corresponding values of DOXO and the selectivity indexes exceed the corresponding SI value of DOXO. The tested compounds demonstrated a high antioxidant effect against ABTS(center dot+) radical cations as well as low toxicity on Daphnia magna.
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